Source:http://linkedlifedata.com/resource/pubmed/id/12006592
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
27
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| pubmed:dateCreated |
2002-7-1
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| pubmed:abstractText |
Insulin receptor substrate p53/p58 (IRSp53) is involved in cytoskeletal dynamics and is a candidate disease sensor in polyglutamine expansion neurodegeneration. It is widely expressed throughout the body, but its levels are dramatically elevated in forebrain regions. IRSp53 functions as a signal transducing adaptor between activated Rho family GTPases and their effectors. There are four known alternatively spliced isoforms of IRSp53 that vary by the identity of the 3'-terminal exon. We report here that there is a fifth alternatively spliced isoform, IRSp53-B, which lacks 40 amino acids abutting the CRIB/SH3 (Cdc42/Rac-interactive binding/Src homology 3)-binding site. We speculate that the novel form has an altered function related to the mechanism of autoinactivation. IRSp53-B has an odd history in the mammalian lineage, which may complicate the use of rodent models to study cytoskeletal reorganization.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
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| pubmed:issn |
0021-9258
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
5
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| pubmed:volume |
277
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
24728-34
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12006592-Alternative Splicing,
pubmed-meshheading:12006592-Amino Acid Sequence,
pubmed-meshheading:12006592-Animals,
pubmed-meshheading:12006592-Base Sequence,
pubmed-meshheading:12006592-Binding, Competitive,
pubmed-meshheading:12006592-Binding Sites,
pubmed-meshheading:12006592-Consensus Sequence,
pubmed-meshheading:12006592-Humans,
pubmed-meshheading:12006592-Mice,
pubmed-meshheading:12006592-Molecular Sequence Data,
pubmed-meshheading:12006592-Nerve Tissue Proteins,
pubmed-meshheading:12006592-Protein Isoforms,
pubmed-meshheading:12006592-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12006592-Sequence Alignment,
pubmed-meshheading:12006592-Sequence Homology, Amino Acid,
pubmed-meshheading:12006592-Sequence Homology, Nucleic Acid,
pubmed-meshheading:12006592-Signal Transduction,
pubmed-meshheading:12006592-src Homology Domains
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| pubmed:year |
2002
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| pubmed:articleTitle |
Novel isoform of insulin receptor substrate p53/p58 is generated by alternative splicing in the CRIB/SH3-binding region.
|
| pubmed:affiliation |
Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|