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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5575
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pubmed:dateCreated |
2002-6-14
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pubmed:databankReference |
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pubmed:abstractText |
Comparison of the whole-genome sequence of Bacillus anthracis isolated from a victim of a recent bioterrorist anthrax attack with a reference reveals 60 new markers that include single nucleotide polymorphisms (SNPs), inserted or deleted sequences, and tandem repeats. Genome comparison detected four high-quality SNPs between the two sequenced B. anthracis chromosomes and seven differences among different preparations of the reference genome. These markers have been tested on a collection of anthrax isolates and were found to divide these samples into distinct families. These results demonstrate that genome-based analysis of microbial pathogens will provide a powerful new tool for investigation of infectious disease outbreaks.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1095-9203
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pubmed:author |
pubmed-author:BuschJoseph DJD,
pubmed-author:FraserClaire MCM,
pubmed-author:HoltzappleErikE,
pubmed-author:JiangLingxiaL,
pubmed-author:KeimPaulP,
pubmed-author:PopMihaiM,
pubmed-author:ReadTimothy DTD,
pubmed-author:SalzbergSteven LSL,
pubmed-author:SchuppJames MJM,
pubmed-author:ShumwayMartinM,
pubmed-author:SmithKimothy LKL,
pubmed-author:SolomonDanielD,
pubmed-author:UmayamLowellL
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pubmed:issnType |
Electronic
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pubmed:day |
14
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pubmed:volume |
296
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2028-33
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12004073-Animals,
pubmed-meshheading:12004073-Anthrax,
pubmed-meshheading:12004073-Bacillus anthracis,
pubmed-meshheading:12004073-Bacterial Typing Techniques,
pubmed-meshheading:12004073-Base Sequence,
pubmed-meshheading:12004073-Bioterrorism,
pubmed-meshheading:12004073-Chromosome Inversion,
pubmed-meshheading:12004073-Computational Biology,
pubmed-meshheading:12004073-Disease Outbreaks,
pubmed-meshheading:12004073-Genetic Markers,
pubmed-meshheading:12004073-Genetic Variation,
pubmed-meshheading:12004073-Genome, Bacterial,
pubmed-meshheading:12004073-Genomics,
pubmed-meshheading:12004073-Humans,
pubmed-meshheading:12004073-Minisatellite Repeats,
pubmed-meshheading:12004073-Molecular Sequence Data,
pubmed-meshheading:12004073-Mutation,
pubmed-meshheading:12004073-Phenotype,
pubmed-meshheading:12004073-Phylogeny,
pubmed-meshheading:12004073-Plasmids,
pubmed-meshheading:12004073-Polymorphism, Single Nucleotide,
pubmed-meshheading:12004073-Recombination, Genetic,
pubmed-meshheading:12004073-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:12004073-Sequence Analysis, DNA,
pubmed-meshheading:12004073-Sequence Deletion,
pubmed-meshheading:12004073-Species Specificity,
pubmed-meshheading:12004073-Transposases,
pubmed-meshheading:12004073-Virulence
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pubmed:year |
2002
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pubmed:articleTitle |
Comparative genome sequencing for discovery of novel polymorphisms in Bacillus anthracis.
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pubmed:affiliation |
The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, MD 20850, USA., Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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