12003644

Source:http://linkedlifedata.com/resource/pubmed/id/12003644

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0017262, umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0025219, umls-concept:C0079904, umls-concept:C0185117, umls-concept:C0205263, umls-concept:C0392756, umls-concept:C2911684
pubmed:dateCreated	2002-11-19
pubmed:abstractText	Endothelial MAdCAM-1 (mucosal addressin cell adhesion molecule-1) expression is associated with the oxidant-dependent induction and progress of inflammatory bowel disease (IBD). Melatonin, a relatively safe, potent antioxidant, has shown efficacy in several chronic injury models may limit MAdCAM-1 expression and therefore have a therapeutic use in IBD.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/DK43785, http://linkedlifedata.com/resource/pubmed/grant/DK47663, http://linkedlifedata.com/resource/pubmed/grant/HL47615
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pubmed:language	eng
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins, http://linkedlifedata.com/resource/pubmed/chemical/MADCAM1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Melatonin, http://linkedlifedata.com/resource/pubmed/chemical/Mucoproteins, http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lymphocyte Homing, http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
pubmed:status	MEDLINE
pubmed:author	pubmed-author:AlexanderSteven JSJ, pubmed-author:ItohMakotohM, pubmed-author:JenkinsMichaelM, pubmed-author:JohTakashiT, pubmed-author:JordanPaulP, pubmed-author:MinagarAlirezaA, pubmed-author:PavlickKevinK, pubmed-author:SasakiMakotoM
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	9
pubmed:dateRevised	2009-11-18
pubmed:articleTitle	Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kappaB.
pubmed:affiliation	LSU Health Sciences Center-Shreveport Molecular and Cellular Physiology, 1501 Kings Highway, Shreveport, Louisiana 71130-3932, USA. msasak@lsuhsc.edu