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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-5-10
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pubmed:abstractText |
A new D-glucose-6-phosphate phosphohydrolase (G6Pase) inhibitor, CJ-21,164 (1) was isolated from the fermentation broth of the fungus Chloridium sp. CL48903. The structure was elucidated to be a novel tetramer of the salicylic acid derivatives by spectroscopic analyses. Compound I inhibited G6Pase in rat liver microsomes with an IC50 of 1.6 microM. Glucose output from hepatocytes isolated from rat liver was inhibited when I was present in the incubation medium, consistent with the role of I as a G6Pase inhibitor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-8820
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12002992-Animals,
pubmed-meshheading:12002992-Benzoates,
pubmed-meshheading:12002992-Enzyme Inhibitors,
pubmed-meshheading:12002992-Fermentation,
pubmed-meshheading:12002992-Glucose,
pubmed-meshheading:12002992-Male,
pubmed-meshheading:12002992-Microsomes, Liver,
pubmed-meshheading:12002992-Molecular Structure,
pubmed-meshheading:12002992-Phosphoric Monoester Hydrolases,
pubmed-meshheading:12002992-Rats,
pubmed-meshheading:12002992-Rats, Sprague-Dawley
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pubmed:year |
2002
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pubmed:articleTitle |
CJ-21,164, a new D-glucose-6-phosphate phosphohydrolase inhibitor produced by a fungus Chloridium sp.
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pubmed:affiliation |
Exploratory Medicinal Sciences, PGRD, Nagoya Laboratories, Pfizer Pharmaceuticals Inc, Chita-gun, Aichi, Japan. Yoon-Jeong.Kim@japan.pfizer.com
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pubmed:publicationType |
Journal Article
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