Source:http://linkedlifedata.com/resource/pubmed/id/12002764
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2002-5-10
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| pubmed:abstractText |
A rare subset of HIV lymphoma, known as primary effusion lymphoma (PEL), is a high-grade tumour carrying human herpes virus 8 (HHV-8). Very little is known about genomic aberration in PEL, and only a few HIV-negative PEL have been reported. Here we report the results of chromosomal analysis and comparative genomic hybridisation (CGH) conducted to detect regions of gain and loss, in five HIV-negative Japanese cases of HHV-8-negative PEL. All patients except one (35-year-old female) were elderly men and the morphologic examination showed large cell type. PEL expressed B-cell-associated and activation-associated antigens, and exhibited clonal immunoglobulin genes. No HHV-8 was detected in all four examined cases, but Epstein-Barr virus (EBV) was detected in one case. Genomic abnormalities and aberrations were identified in all HHV-8/HIV-negative PEL. CGH studies showed gain in 19 of 24 chromosomes. Gains of 3q13-27, 8q24, 10q21-23 and Yq were detected in two of the five cases, but other gains were noted in each case. Chromosomal analysis revealed complex abnormalities both in numbers and structures. Burkitt lymphoma-associated t(8;22) was detected in one case, but +8 chromosome and c-myc amplification were detected in the other three cases by Southern blot and/or fluorecence in situ hybridization (FISH). Abnormality of chromosome 8, which associates with c-myc, was detected in four of the five HHV-8/HIV-negative PEL. However, the other common genomic abnormalities of HHV-8/HIV-negative PEL were not detected in our study, but the complex abnormalities seemed to be true rather than the usual large B-cell lymphoma. Our results suggest that multi-step genomic abnormalities might be associated in HHV-8/HIV-negative PEL tumorigenesis.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1042-8194
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| pubmed:author |
pubmed-author:IshiguroMasakoM,
pubmed-author:KawasakiChikaC,
pubmed-author:KikuchiMasahiroM,
pubmed-author:MiyagiJunichiJ,
pubmed-author:MutaTsutomuT,
pubmed-author:OhshimaKoichiK,
pubmed-author:OkamuraSeichiS,
pubmed-author:SasakiHidenoriH,
pubmed-author:SugioYasuhiroY,
pubmed-author:TuchiyaTakeshiT,
pubmed-author:YamasakiSatoshiS
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| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
595-601
|
| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12002764-Adult,
pubmed-meshheading:12002764-Aged,
pubmed-meshheading:12002764-Aged, 80 and over,
pubmed-meshheading:12002764-Antibodies, Viral,
pubmed-meshheading:12002764-Chromosome Aberrations,
pubmed-meshheading:12002764-Cytogenetic Analysis,
pubmed-meshheading:12002764-Female,
pubmed-meshheading:12002764-Genes, myc,
pubmed-meshheading:12002764-HIV Seronegativity,
pubmed-meshheading:12002764-Herpesvirus 4, Human,
pubmed-meshheading:12002764-Herpesvirus 8, Human,
pubmed-meshheading:12002764-Humans,
pubmed-meshheading:12002764-Japan,
pubmed-meshheading:12002764-Lymphoma, B-Cell,
pubmed-meshheading:12002764-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:12002764-Male,
pubmed-meshheading:12002764-Middle Aged,
pubmed-meshheading:12002764-Nucleic Acid Hybridization,
pubmed-meshheading:12002764-Pleural Effusion, Malignant
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Chromosomal and comparative genomic analyses of HHV-8-negative primary effusion lymphoma in five HIV-negative Japanese patients.
|
| pubmed:affiliation |
Department of Pathology, School of Medicine, Fukuoka University, Japan.
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| pubmed:publicationType |
Journal Article
|