Source:http://linkedlifedata.com/resource/pubmed/id/12002755
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2002-5-10
|
| pubmed:abstractText |
We have studied the expression of MIB-1 and prognosis in cyclin D1(CyD1)+ and CyD1- mantle cell lymphoma (MCL), and compared them to B-CLL/SLL. All cases were assigned to four groups by immunoreactivity and primary sites: (1) CyD1+ nodal MCL, 11 cases: (2) CyD1+ extranodal MCL (multiple lymphomatous polyposis, (MLP)) three cases: (3) CyD1- nodal MCL, three cases: and (4) CyD1- B-CLL/SLL, seven cases. The average of MIB-1 labeling indexes of the four groups were 30.66, 8.70, 9.30 and 4.66, respectively. The CyD1- group consisting of nodal MCL and CLL/SLL had a significantly longer median survival time (69 months) than the CyD1+ group consisting of nodal MCL and MLP (22 months, P = 0.01). These data indicate that CyD1- nodal MCL may show a lower MIB-1 labeling index, and has a better prognosis, than CyD1+ nodal MCL. In addition, a large difference in the average of MIB-1 labeling indexes between nodal MCL and MLP in the CyD1+ group was found.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
1042-8194
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
523-30
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12002755-Aged,
pubmed-meshheading:12002755-Aged, 80 and over,
pubmed-meshheading:12002755-Biological Markers,
pubmed-meshheading:12002755-Chronic Disease,
pubmed-meshheading:12002755-Cyclin D1,
pubmed-meshheading:12002755-Disease Progression,
pubmed-meshheading:12002755-Female,
pubmed-meshheading:12002755-Humans,
pubmed-meshheading:12002755-Immunohistochemistry,
pubmed-meshheading:12002755-Ki-67 Antigen,
pubmed-meshheading:12002755-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:12002755-Lymphoma, B-Cell,
pubmed-meshheading:12002755-Lymphoma, Mantle-Cell,
pubmed-meshheading:12002755-Male,
pubmed-meshheading:12002755-Middle Aged,
pubmed-meshheading:12002755-Neoplasm Proteins,
pubmed-meshheading:12002755-Prognosis,
pubmed-meshheading:12002755-Retrospective Studies,
pubmed-meshheading:12002755-Survival Analysis
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
The evaluation of the biological behavior and grade among cases with mantle cell lymphoma.
|
| pubmed:affiliation |
Department of Pathology, Fukushima Medical University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|