| pubmed-article:12000358 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12000358 | lifeskim:mentions | umls-concept:C0032105 | lld:lifeskim |
| pubmed-article:12000358 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:12000358 | lifeskim:mentions | umls-concept:C0023820 | lld:lifeskim |
| pubmed-article:12000358 | lifeskim:mentions | umls-concept:C0003591 | lld:lifeskim |
| pubmed-article:12000358 | lifeskim:mentions | umls-concept:C0085201 | lld:lifeskim |
| pubmed-article:12000358 | lifeskim:mentions | umls-concept:C0042333 | lld:lifeskim |
| pubmed-article:12000358 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:12000358 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:12000358 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:12000358 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12000358 | pubmed:dateCreated | 2002-5-9 | lld:pubmed |
| pubmed-article:12000358 | pubmed:abstractText | The present authors investigated the individual and combined associations of the apolipoprotein (apo) A-I -75 bp and +83 bp polymorphisms with plasma lipid, lipoprotein and apolipoprotein levels in 734 Caucasian men and women. The frequency of the A allele at position -75 bp (G-->A) was 0.14 in women and 0.17 in men. The frequencies for the rare M2 allele at position +83 bp and/or 84 bp (C-->T and G-->A, respectively) were 0.04 and 0.05 in women and men, respectively. In women, the A allele was associated with significantly higher levels of apo B (P = 0.016), total cholesterol (TC) (P = 0.005), low-density lipoprotein cholesterol (LDL-C) (P = 0.018) and TC:high-density lipoprotein (HDL) ratio (P = 0.026) compared to the G/G subjects. In men, no significant associations were detected between the -75 bp polymorphism and any lipid trait examined. The M2 allele for the +83 bp polymorphism was significantly associated in men with higher levels of apo A-I (P = 0.002) and TC (P = 0.046). In women, a significant effect was observed for TC (P = 0.036), with M2+/- subjects having lower levels than M2+/+ subjects. Significant linkage disequilibrium (P = 0.037) between the apo A-I -75 bp and +83 bp polymorphisms was detected. Women carrying both rare alleles (G/A M2+/-) had significantly higher TC:HDL ratios (P = 0.031) compared to the other haplotypes. In men, significant differences were observed for apo A-I (P = 0.021) and TC (P = 0.044), with carriers of the G/G M2+/- haplotype having the highest values compared to other genotype combinations. In conclusion, the -75 bp (G/A) polymorphism appears to have a significant effect on levels of apo B, plasma TC and LDL-C in women, while the +83 bp polymorphism seems to affect the apo A-I levels in men, and the plasma cholesterol levels in both genders. | lld:pubmed |
| pubmed-article:12000358 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12000358 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12000358 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12000358 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12000358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12000358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12000358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12000358 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12000358 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12000358 | pubmed:issn | 0009-9163 | lld:pubmed |
| pubmed-article:12000358 | pubmed:author | pubmed-author:SchaeferE JEJ | lld:pubmed |
| pubmed-article:12000358 | pubmed:author | pubmed-author:OrdovasJ MJM | lld:pubmed |
| pubmed-article:12000358 | pubmed:author | pubmed-author:FeussnerGG | lld:pubmed |
| pubmed-article:12000358 | pubmed:author | pubmed-author:Lamon-FavaSS | lld:pubmed |
| pubmed-article:12000358 | pubmed:author | pubmed-author:HoffmannM MMM | lld:pubmed |
| pubmed-article:12000358 | pubmed:author | pubmed-author:BarnardJ RJR | lld:pubmed |
| pubmed-article:12000358 | pubmed:author | pubmed-author:LarsonI AIA | lld:pubmed |
| pubmed-article:12000358 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12000358 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:12000358 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12000358 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12000358 | pubmed:pagination | 176-84 | lld:pubmed |
| pubmed-article:12000358 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12000358 | pubmed:meshHeading | pubmed-meshheading:12000358... | lld:pubmed |
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| pubmed-article:12000358 | pubmed:meshHeading | pubmed-meshheading:12000358... | lld:pubmed |
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| pubmed-article:12000358 | pubmed:meshHeading | pubmed-meshheading:12000358... | lld:pubmed |
| pubmed-article:12000358 | pubmed:meshHeading | pubmed-meshheading:12000358... | lld:pubmed |
| pubmed-article:12000358 | pubmed:meshHeading | pubmed-meshheading:12000358... | lld:pubmed |
| pubmed-article:12000358 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12000358 | pubmed:articleTitle | Effects of apolipoprotein A-I genetic variations on plasma apolipoprotein, serum lipoprotein and glucose levels. | lld:pubmed |
| pubmed-article:12000358 | pubmed:affiliation | Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Tufts University School of Medicine, New England Medical Center, Boston, MA, USA. | lld:pubmed |
| pubmed-article:12000358 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12000358 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12000358 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12000358 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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