Linked Life Data

11998979

Source:http://linkedlifedata.com/resource/pubmed/id/11998979

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-5-9
pubmed:abstractText
The development of the mammalian heart is characterized by substantial changes in myocardial performance. We studied the ontogeny of myocardial function with and without various inotropic interventions in the developing isolated, antegrade-perfused rabbit heart (2d, 8d, 14d, 28d, n = 96). Myocardial function was related to the protein expression of the sarcolemmal Na(+)-Ca2+ exchanger and to the sarcoplasmic Ca(2+)-ATPase. In neonatal hearts an age-dependent increase in maximal developed pressure velocity (dP/dtmax) by 45% and peak negative pressure velocity (dP/ dtmin) by 75% within days 2 to 8 were observed. In response to inotropic intervention with isoproterenol, ouabain, calcium and the Na(+)-channel modulator BDF 9148, dP/dtmax and dP/dtmin increased in a concentration dependent manner. Significant differences between neonatal, juvenile and adult hearts could be demonstrated in a repeated measurement ANOVA model on the concentration-response curves for BDF 9148 (dP/dtmax and dP/dtmin), ouabain (dP/dtmin) and calcium (dP/dtmin), but not for isoproterenol. At the maximum isoproterenol concentration of 1 micromol/l, the increase in dP/dtmax and dP/dtmin was significantly higher in adult compared to neonatal hearts (t-test, p < 0.01). The significant decline of the Na(+)-Ca2+ exchanger protein expression from neonatal (1822 +/- 171) to adult hearts (411 +/- 96 S.E.M. [units per 20 microg protein], p < 0.01) was related to an increase in myocardial function (dP/dtmax r = 0.63, p < 0.01, dP/dtmin r = 0.62, p < 0.01). Contractility, relaxation and the observed positive inotropic effects were in general significantly lower in neonatal compared to adult hearts. In the individual heart an increase in contractility and relaxation was related to a decrease in Na(+)-Ca2+ exchanger expression.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0300-8428
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
76-87
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:11998979-Adrenergic beta-Agonists, pubmed-meshheading:11998979-Aging, pubmed-meshheading:11998979-Animals, pubmed-meshheading:11998979-Animals, Newborn, pubmed-meshheading:11998979-Azetidines, pubmed-meshheading:11998979-Calcium, pubmed-meshheading:11998979-Calcium-Transporting ATPases, pubmed-meshheading:11998979-Cardiotonic Agents, pubmed-meshheading:11998979-Enzyme Inhibitors, pubmed-meshheading:11998979-Female, pubmed-meshheading:11998979-Gene Expression, pubmed-meshheading:11998979-Heart, pubmed-meshheading:11998979-Isoproterenol, pubmed-meshheading:11998979-Male, pubmed-meshheading:11998979-Myocardial Contraction, pubmed-meshheading:11998979-Myocardium, pubmed-meshheading:11998979-Ouabain, pubmed-meshheading:11998979-Rabbits, pubmed-meshheading:11998979-Sarcoplasmic Reticulum, pubmed-meshheading:11998979-Sodium-Calcium Exchanger, pubmed-meshheading:11998979-Ventricular Pressure
pubmed:year
2002
pubmed:articleTitle
Effects of different inotropic interventions on myocardial function in the developing rabbit heart.
pubmed:affiliation
Department of Pediatrics, University of Göttingen, Germany. schiffi@med.uni-goettingen.de
pubmed:publicationType
Journal Article, In Vitro