Linked Life Data

11998681

Source:http://linkedlifedata.com/resource/pubmed/id/11998681

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-5-9
pubmed:abstractText
Widespread myelination by oligodendrocytes is essential for the normal functioning of the vertebrate CNS. Oligodendrocyte precursors initially arise in restricted regions of the neuroepithelium and migrate relatively long distances to their final destinations. The signals that guide this migration have remained poorly understood, but recent studies suggest that glial precursors use similar molecular cues to those that guide axons through the complex terrain of the developing CNS. For example, in the developing optic nerve, glial-precursor migration from the brain towards the retina is guided by netrin-1 and semaphorin 3a. These studies suggest a novel mechanism governing glial precursor migration and provide new insights into development and the potential to direct CNS injury repair.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0166-2236
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
173-5; discussion 175-6
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Glial cell migration directed by axon guidance cues.
pubmed:affiliation
Dept of Neurosciences, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.
pubmed:publicationType
Journal Article, Review