Linked Life Data

11997712

Source:http://linkedlifedata.com/resource/pubmed/id/11997712

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-5-8
pubmed:abstractText
Using the signal sequence trap method, we have identified a cDNA clone coding for a type I transmembrane protein, BET, with 10 epidermal growth factor (EGF) motifs in the extracellular domain. In situ hybridization revealed that the bet mRNA is specifically expressed in the mitral/tufted cells in the olfactory bulb, Purkinje cells in the cerebellum, and pyramidal cells in the hippocampus. Using polyclonal antibodies, we have demonstrated that the BET protein is highly glycosylated and is localized in patches in the dendrites and in the somata of neurons. Since the predicted structure of BET shares many similarities with the Notch ligands, this novel protein may play crucial roles in establishing the neuronal networks in the olfactory system, cerebellum, and hippocampus. BET is the first transmembrane protein containing only multiple EGF-like repeats specifically expressed in the brain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
909-15
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11997712-Animals, pubmed-meshheading:11997712-Animals, Newborn, pubmed-meshheading:11997712-Blotting, Western, pubmed-meshheading:11997712-Body Patterning, pubmed-meshheading:11997712-Brain, pubmed-meshheading:11997712-COS Cells, pubmed-meshheading:11997712-Cell Differentiation, pubmed-meshheading:11997712-Cell Membrane, pubmed-meshheading:11997712-Cerebellum, pubmed-meshheading:11997712-DNA, Complementary, pubmed-meshheading:11997712-Epidermal Growth Factor, pubmed-meshheading:11997712-Gene Expression Regulation, pubmed-meshheading:11997712-Humans, pubmed-meshheading:11997712-Membrane Proteins, pubmed-meshheading:11997712-Mice, pubmed-meshheading:11997712-Microtubule-Associated Proteins, pubmed-meshheading:11997712-Molecular Sequence Data, pubmed-meshheading:11997712-Nerve Tissue Proteins, pubmed-meshheading:11997712-Neurons, pubmed-meshheading:11997712-Protein Structure, Tertiary, pubmed-meshheading:11997712-RNA, Messenger, pubmed-meshheading:11997712-Receptors, Cell Surface, pubmed-meshheading:11997712-Sequence Homology, Amino Acid, pubmed-meshheading:11997712-Sequence Homology, Nucleic Acid
pubmed:year
2002
pubmed:articleTitle
BET, a novel neuronal transmembrane protein with multiple EGF-like motifs.
pubmed:affiliation
Department of Biophysics, Central Technology Laboratory, Asahi Kasei Corporation, 2-1 Samejima, Fuji, Shizuoka 416-8501, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't