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rdf:type |
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lifeskim:mentions |
umls-concept:C0025260,
umls-concept:C0039194,
umls-concept:C0079411,
umls-concept:C0085358,
umls-concept:C0152060,
umls-concept:C0205154,
umls-concept:C0205225,
umls-concept:C0254610,
umls-concept:C1306235,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1514873,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
10
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pubmed:dateCreated |
2002-5-7
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pubmed:abstractText |
IL-15 and IL-15Ralpha are required for generation of memory-phenotype CD8 T cells in unimmunized mice. However, the role of IL-15 in primary expansion and generation of Ag-specific memory CD8 T cells in vivo has not been investigated. We characterized the CD8 T cell response against vesicular stomatitis virus (VSV) in IL-15(-/-) and IL-15Ralpha(-/-) mice. Surprisingly, IL-15 was required for primary expansion of VSV-specific CD8 T cells. The generation of VSV-specific memory CD8 T cells was also impaired without IL-15 signaling, and this defect correlated with a decrease in memory CD8 T cell turnover. Despite minimal proliferation without IL-15, a subset of memory cells survived long-term. IL-15Ralpha expression was low on naive CD8 T cells, up-regulated on Ag-specific effector cells, and sustained on memory cells. Thus, IL-15 was important for the generation and the subsequent maintenance of antiviral memory CD8 T cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD44,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Il15ra protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
168
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4827-31
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11994430-Animals,
pubmed-meshheading:11994430-Antigens, CD44,
pubmed-meshheading:11994430-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11994430-Cell Division,
pubmed-meshheading:11994430-Epitopes, T-Lymphocyte,
pubmed-meshheading:11994430-Immunologic Memory,
pubmed-meshheading:11994430-Interleukin-15,
pubmed-meshheading:11994430-Interphase,
pubmed-meshheading:11994430-Lymphocyte Activation,
pubmed-meshheading:11994430-Mice,
pubmed-meshheading:11994430-Mice, Inbred C57BL,
pubmed-meshheading:11994430-Mice, Knockout,
pubmed-meshheading:11994430-Receptors, Interleukin-15,
pubmed-meshheading:11994430-Receptors, Interleukin-2,
pubmed-meshheading:11994430-Rhabdoviridae Infections,
pubmed-meshheading:11994430-T-Lymphocyte Subsets,
pubmed-meshheading:11994430-Vesicular stomatitis Indiana virus
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pubmed:year |
2002
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pubmed:articleTitle |
Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells.
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pubmed:affiliation |
Division of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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