Source:http://linkedlifedata.com/resource/pubmed/id/11992785
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
2002-5-6
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pubmed:abstractText |
We have designed and synthesized novel antiviral nucleoside analogues, which consist of isoxazole rings as modified sugars and nucleobases (thymine, uracil, and 5-fluorouracil) with a methylene linker between them. These compounds represent a new class of modified nucleoside analogues and some of them show potent antiviral activities against Polio virus (Coxsackie B type 3 and Vesicular Stomatitis).
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1395-7
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11992785-Antiviral Agents,
pubmed-meshheading:11992785-Drug Design,
pubmed-meshheading:11992785-Enterovirus B, Human,
pubmed-meshheading:11992785-Heterocyclic Compounds,
pubmed-meshheading:11992785-Isoxazoles,
pubmed-meshheading:11992785-Microbial Sensitivity Tests,
pubmed-meshheading:11992785-Models, Molecular,
pubmed-meshheading:11992785-Molecular Conformation,
pubmed-meshheading:11992785-Nucleosides,
pubmed-meshheading:11992785-Poliovirus,
pubmed-meshheading:11992785-Structure-Activity Relationship,
pubmed-meshheading:11992785-Vesicular stomatitis Indiana virus
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pubmed:year |
2002
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pubmed:articleTitle |
Heterocyclic nucleoside analogues: design and synthesis of antiviral, modified nucleosides containing isoxazole heterocycles.
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pubmed:affiliation |
National Research Laboratory, Department of Chemistry, Center for Integrated Molecular Systems, Division of Molecular and Life Sciences, Pohang University of Science and Technology, 790-784, Pohang, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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