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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2002-5-6
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pubmed:abstractText |
A piperazinylbutylisoxazole libary was designed, synthesized and screened for the binding affinities to dopamine D2, D3, and D4 receptors. Several ligands were identified to possess high binding affinity and selectivity for the D3 and D4 receptors over the D2 receptor. Compounds 6s and 6t showed K(i) values of 2.6 nM and 3.9 nM for the D3 receptor with 46- and 50-fold selectivity over the D2 receptor, respectively.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1327-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11992769-Animals,
pubmed-meshheading:11992769-Binding Sites,
pubmed-meshheading:11992769-CHO Cells,
pubmed-meshheading:11992769-Cloning, Molecular,
pubmed-meshheading:11992769-Cricetinae,
pubmed-meshheading:11992769-Drug Design,
pubmed-meshheading:11992769-Humans,
pubmed-meshheading:11992769-Isoxazoles,
pubmed-meshheading:11992769-Kinetics,
pubmed-meshheading:11992769-Ligands,
pubmed-meshheading:11992769-Piperazines,
pubmed-meshheading:11992769-Receptors, Dopamine,
pubmed-meshheading:11992769-Recombinant Proteins,
pubmed-meshheading:11992769-Spiperone,
pubmed-meshheading:11992769-Structure-Activity Relationship,
pubmed-meshheading:11992769-Transfection
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pubmed:year |
2002
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pubmed:articleTitle |
Design and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands.
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pubmed:affiliation |
Biochemicals Research Center, Korea Institute of Science and Technology, Cheongrayang, 130-650, Seoul, South Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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