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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-5-23
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pubmed:abstractText |
Epidermal growth factor receptor (EGF-R) autophosphorylation is essential for its intracellular mitogenic signaling via the MAPK pathway and for interaction in other cellular processes. Inhibition of this activity in tumor cells that predominantly utilise EGF-R therefore offers an alternative approach to therapy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0270-4137
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
59-68
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11992620-Adenocarcinoma,
pubmed-meshheading:11992620-Apoptosis,
pubmed-meshheading:11992620-Blotting, Northern,
pubmed-meshheading:11992620-Blotting, Western,
pubmed-meshheading:11992620-Cell Count,
pubmed-meshheading:11992620-Cell Cycle,
pubmed-meshheading:11992620-Cell Division,
pubmed-meshheading:11992620-Enzyme Activation,
pubmed-meshheading:11992620-Enzyme Inhibitors,
pubmed-meshheading:11992620-Epidermal Growth Factor,
pubmed-meshheading:11992620-Humans,
pubmed-meshheading:11992620-Immunohistochemistry,
pubmed-meshheading:11992620-Male,
pubmed-meshheading:11992620-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11992620-Neoplasm Invasiveness,
pubmed-meshheading:11992620-Phosphorylation,
pubmed-meshheading:11992620-Prostatic Neoplasms,
pubmed-meshheading:11992620-Quinazolines,
pubmed-meshheading:11992620-RNA, Messenger,
pubmed-meshheading:11992620-Receptor, Epidermal Growth Factor,
pubmed-meshheading:11992620-Signal Transduction,
pubmed-meshheading:11992620-Transforming Growth Factor alpha,
pubmed-meshheading:11992620-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Multiple responses to EGF receptor activation and their abrogation by a specific EGF receptor tyrosine kinase inhibitor.
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pubmed:affiliation |
Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff, United Kingdom. HarperME1@Cardiff.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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