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rdf:type |
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lifeskim:mentions |
umls-concept:C0006556,
umls-concept:C0008633,
umls-concept:C0009015,
umls-concept:C0017262,
umls-concept:C0017428,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0185117,
umls-concept:C0205245,
umls-concept:C0205314,
umls-concept:C0678594,
umls-concept:C0679622,
umls-concept:C1283195,
umls-concept:C1880022,
umls-concept:C2911684
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|
pubmed:issue |
5
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|
pubmed:dateCreated |
2002-5-6
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|
pubmed:databankReference |
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|
pubmed:abstractText |
Drebrin A, a major neuronal actin-binding protein, regulates the dendritic spine shapes of neurons. Here, we have cloned and characterized a novel mouse cDNA clone encoding a truncated form of drebrin A, named s-drebrin A. Analysis of the genomic organization of the mouse drebrin gene (Dbn1), which mapped to the central portion of chromosome 13, revealed that isoforms including s-drebrin A are generated by alternative splicing from a single drebrin gene. The s-drebrin A mRNA was expressed in the brain, but not in non-neuronal tissues. The s-drebrin A expression was barely detected in the embryonic brain, but was upregulated during postnatal development of the brain. Overexpression of GFP-tagged s-drebrin A in fibroblasts showed it to be associated with actin filaments and with changes in actin cytoskeleton organization. These findings suggest that s-drebrin A has a role in spine morphogenesis, possibly by competing the actin-binding activity with drebrin A.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0888-7543
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
79
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
686-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11991718-Actins,
pubmed-meshheading:11991718-Animals,
pubmed-meshheading:11991718-Base Sequence,
pubmed-meshheading:11991718-Brain,
pubmed-meshheading:11991718-CHO Cells,
pubmed-meshheading:11991718-Chromosome Mapping,
pubmed-meshheading:11991718-Cloning, Molecular,
pubmed-meshheading:11991718-Cricetinae,
pubmed-meshheading:11991718-Crosses, Genetic,
pubmed-meshheading:11991718-Cytoskeleton,
pubmed-meshheading:11991718-DNA, Complementary,
pubmed-meshheading:11991718-Exons,
pubmed-meshheading:11991718-Female,
pubmed-meshheading:11991718-Gene Expression,
pubmed-meshheading:11991718-Genes,
pubmed-meshheading:11991718-Green Fluorescent Proteins,
pubmed-meshheading:11991718-Introns,
pubmed-meshheading:11991718-Luminescent Proteins,
pubmed-meshheading:11991718-Male,
pubmed-meshheading:11991718-Mice,
pubmed-meshheading:11991718-Mice, Inbred C57BL,
pubmed-meshheading:11991718-Molecular Sequence Data,
pubmed-meshheading:11991718-Muridae,
pubmed-meshheading:11991718-Neuropeptides,
pubmed-meshheading:11991718-Recombinant Fusion Proteins,
pubmed-meshheading:11991718-Sequence Analysis, DNA
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pubmed:year |
2002
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|
pubmed:articleTitle |
A novel, brain-specific mouse drebrin: cDNA cloning, chromosomal mapping, genomic structure, expression, and functional characterization.
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pubmed:affiliation |
Department of Neurobiology and Behavior, Gunma University School of Medicine, 3-39-22 Showamachi, Maebashi,371-8511, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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