| pubmed-article:11988580 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11988580 | lifeskim:mentions | umls-concept:C0001948 | lld:lifeskim |
| pubmed-article:11988580 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11988580 | lifeskim:mentions | umls-concept:C0529997 | lld:lifeskim |
| pubmed-article:11988580 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:11988580 | lifeskim:mentions | umls-concept:C0205421 | lld:lifeskim |
| pubmed-article:11988580 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:11988580 | pubmed:issue | 5569 | lld:pubmed |
| pubmed-article:11988580 | pubmed:dateCreated | 2002-5-3 | lld:pubmed |
| pubmed-article:11988580 | pubmed:abstractText | There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral responses to stress plays a role in the control of long-term alcohol drinking. In mice lacking a functional CRH1 receptor, stress leads to enhanced and progressively increasing alcohol intake. The effect of repeated stress on alcohol drinking behavior appeared with a delay and persisted throughout life. It was associated with an up-regulation of the N-methyl-d-aspartate receptor subunit NR2B. Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism. | lld:pubmed |
| pubmed-article:11988580 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11988580 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11988580 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11988580 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11988580 | pubmed:month | May | lld:pubmed |
| pubmed-article:11988580 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:11988580 | pubmed:author | pubmed-author:HolsboerFlori... | lld:pubmed |
| pubmed-article:11988580 | pubmed:author | pubmed-author:Zieglgänsberg... | lld:pubmed |
| pubmed-article:11988580 | pubmed:author | pubmed-author:WurstWolfgang... | lld:pubmed |
| pubmed-article:11988580 | pubmed:author | pubmed-author:SillaberIngeI | lld:pubmed |
| pubmed-article:11988580 | pubmed:author | pubmed-author:RammesGerhard... | lld:pubmed |
| pubmed-article:11988580 | pubmed:author | pubmed-author:ZimmermannSte... | lld:pubmed |
| pubmed-article:11988580 | pubmed:author | pubmed-author:MahalBeatrice... | lld:pubmed |
| pubmed-article:11988580 | pubmed:author | pubmed-author:SpanagelRaine... | lld:pubmed |
| pubmed-article:11988580 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:11988580 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:11988580 | pubmed:volume | 296 | lld:pubmed |
| pubmed-article:11988580 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11988580 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11988580 | pubmed:pagination | 931-3 | lld:pubmed |
| pubmed-article:11988580 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11988580 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11988580 | pubmed:articleTitle | Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. | lld:pubmed |
| pubmed-article:11988580 | pubmed:affiliation | Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany. sillaber@mpipsykl.mpg.de | lld:pubmed |
| pubmed-article:11988580 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11988580 | pubmed:publicationType | In Vitro | lld:pubmed |
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