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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5569
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pubmed:dateCreated |
2002-5-3
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pubmed:abstractText |
There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral responses to stress plays a role in the control of long-term alcohol drinking. In mice lacking a functional CRH1 receptor, stress leads to enhanced and progressively increasing alcohol intake. The effect of repeated stress on alcohol drinking behavior appeared with a delay and persisted throughout life. It was associated with an up-regulation of the N-methyl-d-aspartate receptor subunit NR2B. Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CRF receptor type 1,
http://linkedlifedata.com/resource/pubmed/chemical/Corticotropin-Releasing Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Ethanol,
http://linkedlifedata.com/resource/pubmed/chemical/NR2B NMDA receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Corticotropin-Releasing...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Kainic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
3
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pubmed:volume |
296
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
931-3
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11988580-Action Potentials,
pubmed-meshheading:11988580-Alcohol Drinking,
pubmed-meshheading:11988580-Alcoholism,
pubmed-meshheading:11988580-Animals,
pubmed-meshheading:11988580-Brain,
pubmed-meshheading:11988580-Corticotropin-Releasing Hormone,
pubmed-meshheading:11988580-Ethanol,
pubmed-meshheading:11988580-Female,
pubmed-meshheading:11988580-Hippocampus,
pubmed-meshheading:11988580-Male,
pubmed-meshheading:11988580-Mice,
pubmed-meshheading:11988580-Mice, Knockout,
pubmed-meshheading:11988580-Models, Animal,
pubmed-meshheading:11988580-Mutation,
pubmed-meshheading:11988580-Receptors, AMPA,
pubmed-meshheading:11988580-Receptors, Corticotropin-Releasing Hormone,
pubmed-meshheading:11988580-Receptors, Kainic Acid,
pubmed-meshheading:11988580-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:11988580-Signal Transduction,
pubmed-meshheading:11988580-Stress, Physiological,
pubmed-meshheading:11988580-Stress, Psychological,
pubmed-meshheading:11988580-Up-Regulation
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pubmed:year |
2002
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pubmed:articleTitle |
Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors.
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pubmed:affiliation |
Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany. sillaber@mpipsykl.mpg.de
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pubmed:publicationType |
Journal Article,
In Vitro
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