Linked Life Data

11987698

Source:http://linkedlifedata.com/resource/pubmed/id/11987698

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2002-5-3
pubmed:abstractText
Recent studies suggest that alpha 2-macroglobulin (alpha 2 m) may play a role in the pathogenesis of Alzheimer's Disease (AD). The presence of alpha 2-macroglobulin G/G genotype is thought to increase the risk of AD. The aim of the study was to analyse alpha 2 m polymorphism in two groups: AD patients (n = 60, F = 41, M. = 19, mean age 73.3 +/- 6.3) and non-demented control group (n = 58, F = 36, M. = 22, mean age 73.1 +/- 8.3, mean MMSE score 27). Frequencies of genotypes A/A, A/G, G/G in AD group were: 0.46: 0.42: 0.12. In control group those frequencies were: 0.40: 0.48: 0.12. The lack of statistically significant difference between G/G frequencies in both groups of patients may suggest that alpha 2-macroglobulin G/G genotype is not a risk factor for AD.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0028-3843
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1013-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
[Alpha2-macroglobulin gene polymorphism in patients with Alzheimer's disease].
pubmed:affiliation
Zespo?u Badawczo-Leczniczego Chorób Zwyrodnieniowych CUN Centrum Medycyny Do?wiadczalnej i Klinicznej PAN/MSWiA. desperat@cmdik.pan.pl
pubmed:publicationType
Journal Article, English Abstract