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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-5-2
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pubmed:abstractText |
In early stages of cutaneous T cell lymphoma (Sézary syndrome) both CD4+CD7- and CD4+CD7+ T cells clonally expand whereas in late stages of the disease CD7- cells are predominant in number, giving rise to the question whether CD7- T cells have a survival advantage in the skin. Galectin-1, a cell-bound lectin, was recently reported to trigger apoptosis in activated CD7+ T cells. Here, we demonstrate that in contrast to activated CD7(+) T cells, quiescent and activated CD69+ CD7- T cells from healthy donors and from Sézary patients are resistant to galectin-1-mediated cell death. CD7- T cells are apoptosis-resistant even during coculture with IFN-gamma-stimulated endothelial cells that constitutively express galectin-1 in high amounts. These data imply that resistance of CD7- T cells to galectin-1-induced apoptosis may contribute to the accumulation of CD7- Sézary T cells during progression of the disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0887-6924
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
840-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11986945-Adjuvants, Immunologic,
pubmed-meshheading:11986945-Adolescent,
pubmed-meshheading:11986945-Adult,
pubmed-meshheading:11986945-Aged,
pubmed-meshheading:11986945-Antigens, CD4,
pubmed-meshheading:11986945-Antigens, CD7,
pubmed-meshheading:11986945-Apoptosis,
pubmed-meshheading:11986945-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11986945-Case-Control Studies,
pubmed-meshheading:11986945-Child,
pubmed-meshheading:11986945-Drug Resistance, Neoplasm,
pubmed-meshheading:11986945-Female,
pubmed-meshheading:11986945-Galectin 1,
pubmed-meshheading:11986945-Hemagglutinins,
pubmed-meshheading:11986945-Humans,
pubmed-meshheading:11986945-Lymphocyte Activation,
pubmed-meshheading:11986945-Male,
pubmed-meshheading:11986945-Middle Aged,
pubmed-meshheading:11986945-Sezary Syndrome
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pubmed:year |
2002
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pubmed:articleTitle |
CD4+CD7- leukemic T cells from patients with Sézary syndrome are protected from galectin-1-triggered T cell death.
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pubmed:affiliation |
Department of Dermatology, The Saarland University Hospital, 66421 Homburg/Saar, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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