11986874

Source:http://linkedlifedata.com/resource/pubmed/id/11986874

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021144, umls-concept:C0079809, umls-concept:C0242485, umls-concept:C1707429
pubmed:issue	5
pubmed:dateCreated	2002-5-2
pubmed:abstractText	This paper reviews and discusses what is known about the relationship between identity in state, allele frequency, inbreeding coefficients, and identity by descent in various uses of these terms. Generic definitions of inbreeding coefficients are given, as ratios of differences of probabilities of identity in state. Then some of their properties are derived from an assumption in terms of differences between distributions of coalescence times of different genes. These inbreeding coefficients give an approximate measurement of how much higher the probability of recent coalescence is for some pair of genes relative to another pair. Such a measure is in general not equivalent to identity by descent; rather, it approximates a ratio of differences of probabilities of identity by descent. These results are contrasted with some other formulas relating identity, allele frequency, and inbreeding coefficients. Additional assumptions are necessary to obtain most of them, and some of these assumptions are not always correct, for example when there is localized dispersal. Therefore, definitions based on such formulas are not always well-formulated. By contrast, the generic definitions are both well-formulated and more broadly applicable.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0373007
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0018-067X
pubmed:author	pubmed-author:RousseyMM
pubmed:issnType	Print
pubmed:volume	88
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	371-80
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:11986874-Gene Frequency, pubmed-meshheading:11986874-Genetics, Population, pubmed-meshheading:11986874-Inbreeding, pubmed-meshheading:11986874-Models, Genetic, pubmed-meshheading:11986874-Terminology as Topic
pubmed:year	2002
pubmed:articleTitle	Inbreeding and relatedness coefficients: what do they measure?
pubmed:affiliation	Laboratoire Génétique et Environnement, Institut des Sciences de l'Evolution, Université de Montpellier II, 34095 Montpellier, France. Rousset@insem.univ-montp2.fr
pubmed:publicationType	Journal Article, Review