Linked Life Data

11986779

Source:http://linkedlifedata.com/resource/pubmed/id/11986779

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2002-5-2
pubmed:abstractText
In the present study, epithelium derived lesions of various pathological manifestations were examined histologically and immunohistochemically for mononuclear cell infiltration. The infiltrate under the transformed epithelium of oral lesions, was examined for differences in the composition of immune mononuclear cells as the epithelium moves from hyperkeratosis through various degrees of dysplasia to squamous cell carcinoma. The study was performed on 53 human tongue tissues diagnosed as hyperkeratosis (11 cases), mild dysplasia (nine cases), moderate and severe dysplasia (14 cases) and squamous cell carcinoma (19 cases). A similar analysis was performed on 30 parotid gland tissues diagnosed as pleomorphic adenoma (14 cases) and carcinoma ex-pleomorphic adenoma (16 cases). Immunohistochemical analysis of various surface markers of the tumour infiltrating immune cells was performed and correlated with the transformation level as defined by morphology and the expression of p53 in the epithelium. The results revealed that, in the tongue lesions, the changes in the epithelium from normal appearance to transformed were accompanied by a corresponding increase in the infiltration of CD4, CD8, CD14, CD19+20, and HLA/DR positive cells. The most significant change was an increase in B lymphocytes in tongue lesions, that was in accordance with the transformation level (P<0.001). In the salivary gland, a significant number of cases did not show an infiltrate. In cases where an infiltrate was present, a similar pattern was observed and the more malignant tissues exhibited a higher degree of immune cell infiltration.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-10454022, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-10709097, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-10722007, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-10745166, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-2179166, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-3093654, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-7542177, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-8707405, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-8760010, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-8782203, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-8816839, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-9191518, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-9324133, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-9415332, http://linkedlifedata.com/resource/pubmed/commentcorrection/11986779-9890456
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0007-0920
pubmed:author
pubmed:copyrightInfo
Copyright 2002 Cancer Research UK
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1444-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Increase in immune cell infiltration with progression of oral epithelium from hyperkeratosis to dysplasia and carcinoma.
pubmed:affiliation
Department of Oral Pathology and Oral Medicine, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel-Aviv University, Tel Aviv, Israel.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't