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rdf:type |
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lifeskim:mentions |
umls-concept:C0005423,
umls-concept:C0007097,
umls-concept:C0011155,
umls-concept:C0017262,
umls-concept:C0032854,
umls-concept:C0033325,
umls-concept:C0033684,
umls-concept:C0069197,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0205195,
umls-concept:C0439849,
umls-concept:C0445223,
umls-concept:C1552599,
umls-concept:C1561558,
umls-concept:C1704787,
umls-concept:C1704807,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
2002-5-2
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pubmed:abstractText |
O(6)-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that transfers methyl groups from O(6)-methylguanine to itself. Alkylation of DNA at the O(6) position of guanine is an important step in the induction of mutations in the organism by alkylating agents. The O(6)-methyl G:T mismatch is recognized by the mismatch-repair (MMR) pathway. The biliary duct is highly exposed to alkylating agents because of its anatomical location.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MLH1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MSH2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MutS Homolog 2 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/O(6)-Methylguanine-DNA...,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1068-9265
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
371-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11986189-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:11986189-Aged,
pubmed-meshheading:11986189-Base Pair Mismatch,
pubmed-meshheading:11986189-Bile Duct Neoplasms,
pubmed-meshheading:11986189-Carcinoma,
pubmed-meshheading:11986189-Carrier Proteins,
pubmed-meshheading:11986189-Chi-Square Distribution,
pubmed-meshheading:11986189-DNA Repair,
pubmed-meshheading:11986189-DNA-Binding Proteins,
pubmed-meshheading:11986189-Female,
pubmed-meshheading:11986189-Gallbladder Neoplasms,
pubmed-meshheading:11986189-Humans,
pubmed-meshheading:11986189-Immunoenzyme Techniques,
pubmed-meshheading:11986189-Male,
pubmed-meshheading:11986189-Middle Aged,
pubmed-meshheading:11986189-MutS Homolog 2 Protein,
pubmed-meshheading:11986189-Neoplasm Proteins,
pubmed-meshheading:11986189-Nuclear Proteins,
pubmed-meshheading:11986189-O(6)-Methylguanine-DNA Methyltransferase,
pubmed-meshheading:11986189-Prognosis,
pubmed-meshheading:11986189-Proto-Oncogene Proteins,
pubmed-meshheading:11986189-Statistics, Nonparametric
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pubmed:year |
2002
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pubmed:articleTitle |
Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma.
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pubmed:affiliation |
Department of Surgery, Saga Medical School, Saga, Japan.
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pubmed:publicationType |
Journal Article
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