Linked Life Data

11984003

Source:http://linkedlifedata.com/resource/pubmed/id/11984003

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-5-1
pubmed:abstractText
Essential hypertension is a prevalent complex polygenic disease and a major risk factor for cardiovascular disease, the leading cause of death in developed countries. Because of its complex and multifactorial nature, its genetic determinants still remain largely unknown. The Dahl salt-sensitive hypertensive rat model exhibits impaired sodium handling, which is hypothesized to play a key role in the pathophysiology of polygenic hypertension. Thus, genes associated with renal regulation of salt and water balance are a priori likely candidates for a causative role in hypertension pathogenesis. The functional properties and renal-specific expression of the recently characterized AngII/AVP receptor suggest a putative modulator role in tubular sodium and fluid reabsorption. Based on these observations, we investigated the potential involvement of the AngII/AVP receptor in salt-sensitive hypertension.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1076-1551
pubmed:author
pubmed:issnType
Print
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
24-32
pubmed:dateRevised
2008-11-20
pubmed:meshHeading
pubmed-meshheading:11984003-Allosteric Regulation, pubmed-meshheading:11984003-Amino Acid Sequence, pubmed-meshheading:11984003-Amino Acid Substitution, pubmed-meshheading:11984003-Angiotensin II, pubmed-meshheading:11984003-Animals, pubmed-meshheading:11984003-Arginine Vasopressin, pubmed-meshheading:11984003-Blood Pressure, pubmed-meshheading:11984003-Chromosome Mapping, pubmed-meshheading:11984003-Crosses, Genetic, pubmed-meshheading:11984003-Cyclic AMP, pubmed-meshheading:11984003-DNA, Complementary, pubmed-meshheading:11984003-Genes, pubmed-meshheading:11984003-Genetic Markers, pubmed-meshheading:11984003-Genetic Predisposition to Disease, pubmed-meshheading:11984003-Hypertension, pubmed-meshheading:11984003-Kidney, pubmed-meshheading:11984003-Ligands, pubmed-meshheading:11984003-Lod Score, pubmed-meshheading:11984003-Male, pubmed-meshheading:11984003-Molecular Sequence Data, pubmed-meshheading:11984003-Quantitative Trait, Heritable, pubmed-meshheading:11984003-Rats, pubmed-meshheading:11984003-Rats, Inbred Dahl, pubmed-meshheading:11984003-Receptors, Angiotensin, pubmed-meshheading:11984003-Receptors, Vasopressin, pubmed-meshheading:11984003-Second Messenger Systems, pubmed-meshheading:11984003-Sequence Homology, pubmed-meshheading:11984003-Sodium, pubmed-meshheading:11984003-Sodium Chloride
pubmed:year
2002
pubmed:articleTitle
The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model.
pubmed:affiliation
Whitaker Cardiovascular Clinic, Boston, MA 02118, USA. nruizo@bu.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.