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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-5-1
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pubmed:abstractText |
Implantation of foreign materials into mice and humans has been noted to result in the appearance of soft tissue sarcomas at the site of implantation. These materials include metal replacement joints and Dacron vascular grafts. In addition, occupational exposure to nickel has been shown to result in an increased risk of carcinogenesis. The molecular mechanisms of foreign body-induced carcinogenesis are not fully understood.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Cdkn2a protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinase Inhibitor...,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Implants,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nickel,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Protein p14ARF,
http://linkedlifedata.com/resource/pubmed/chemical/nickel sulfide
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1076-1551
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11984000-Animals,
pubmed-meshheading:11984000-Carcinogens,
pubmed-meshheading:11984000-CpG Islands,
pubmed-meshheading:11984000-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:11984000-DNA Methylation,
pubmed-meshheading:11984000-Drug Implants,
pubmed-meshheading:11984000-Enzyme Activation,
pubmed-meshheading:11984000-Gene Expression Regulation,
pubmed-meshheading:11984000-Genes, p16,
pubmed-meshheading:11984000-Genes, p53,
pubmed-meshheading:11984000-Genes, ras,
pubmed-meshheading:11984000-Hindlimb,
pubmed-meshheading:11984000-Histiocytoma, Benign Fibrous,
pubmed-meshheading:11984000-MAP Kinase Signaling System,
pubmed-meshheading:11984000-Mice,
pubmed-meshheading:11984000-Mice, Inbred C57BL,
pubmed-meshheading:11984000-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11984000-Muscle Neoplasms,
pubmed-meshheading:11984000-Mutagenesis,
pubmed-meshheading:11984000-Neoplasm Proteins,
pubmed-meshheading:11984000-Nickel,
pubmed-meshheading:11984000-Oxidative Stress,
pubmed-meshheading:11984000-Polymerase Chain Reaction,
pubmed-meshheading:11984000-Reactive Oxygen Species,
pubmed-meshheading:11984000-Tumor Suppressor Protein p14ARF
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pubmed:year |
2002
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pubmed:articleTitle |
Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase.
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pubmed:affiliation |
Department of Medicine, Dermatology, Emory University School of Medicine, Atlanta, GQ 30322, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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