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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-5-1
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pubmed:abstractText |
The p53 tumor suppressor protein is important in cell-cycle control, apoptosis, and DNA repair. Mutations in p53 have been associated with inherited cancer susceptibility. Because there is a difference in the risk of lung cancer among different ethnic groups, we examined associations between ethnicity and three polymorphisms in p53 (one exonic and two intronic) and haplotypes for the three loci and risk of lung cancer. We also examined the functionality of the p53 variants in apoptosis and DNA repair.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0027-8874
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
94
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
681-90
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11983757-African Americans,
pubmed-meshheading:11983757-Apoptosis,
pubmed-meshheading:11983757-Case-Control Studies,
pubmed-meshheading:11983757-DNA Repair,
pubmed-meshheading:11983757-Disease Susceptibility,
pubmed-meshheading:11983757-European Continental Ancestry Group,
pubmed-meshheading:11983757-Female,
pubmed-meshheading:11983757-Genes, p53,
pubmed-meshheading:11983757-Genotype,
pubmed-meshheading:11983757-Haplotypes,
pubmed-meshheading:11983757-Humans,
pubmed-meshheading:11983757-Lung Neoplasms,
pubmed-meshheading:11983757-Male,
pubmed-meshheading:11983757-Mexican Americans,
pubmed-meshheading:11983757-Middle Aged,
pubmed-meshheading:11983757-Polymerase Chain Reaction,
pubmed-meshheading:11983757-Polymorphism, Genetic,
pubmed-meshheading:11983757-Risk Factors,
pubmed-meshheading:11983757-Smoking,
pubmed-meshheading:11983757-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
p53 Genotypes and Haplotypes Associated With Lung Cancer Susceptibility and Ethnicity.
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pubmed:affiliation |
Department of Epidemiology, The University of Texas M. D. Anderson Cancer Center, Houston, 77030, USA. xwu@mail.mdanderson.org
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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