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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-5-1
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pubmed:abstractText |
We examined if axon terminals of dopaminergic neurons might make synapses upon neurokinin-1 receptor (NK1R)-expressing intrinsic neurons in the rat striatum. In a double-immunocytochemical ultrastructural study, dopaminergic terminals were labeled by the immunoperoxidase method for tyrosine hydroxylase (TH), while NK1R-immunoreactivity (-IR) was revealed by the immunogold-silver labeling method. Some TH-immunoreactive (-ir) axon terminals formed synapses of the symmetric or intermediate type on NK1R-ir neuronal profiles; usually on dendritic profiles and rarely on somatic profiles. It was further confirmed by means of triple-immunofluorescence histochemistry that NK1R-ir neurons in close association with TH-ir axon terminals showed nitric oxide synthase (NOS)- or vesicular acetylcholine transporter-IR. Since NK1R-expressing striatal neurons are segregated into cholinergic and somatostatin/NOS-containing intrinsic neurons (Brain Res. 631 (1993) 297; Neurosci. Lett. 310 (2001) 109), the present results indicate that dopaminergic neurons make synapses upon these intrinsic neurons in the striatum.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Neurokinin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Slc18a3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Somatostatin,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine 3-Monooxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Acetylcholine Transport...,
http://linkedlifedata.com/resource/pubmed/chemical/Vesicular Transport Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
324
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9-12
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11983282-Acetylcholine,
pubmed-meshheading:11983282-Animals,
pubmed-meshheading:11983282-Carrier Proteins,
pubmed-meshheading:11983282-Dopamine,
pubmed-meshheading:11983282-Immunohistochemistry,
pubmed-meshheading:11983282-Interneurons,
pubmed-meshheading:11983282-Male,
pubmed-meshheading:11983282-Membrane Transport Proteins,
pubmed-meshheading:11983282-Microscopy, Electron,
pubmed-meshheading:11983282-Neostriatum,
pubmed-meshheading:11983282-Neural Pathways,
pubmed-meshheading:11983282-Nitric Oxide,
pubmed-meshheading:11983282-Nitric Oxide Synthase,
pubmed-meshheading:11983282-Presynaptic Terminals,
pubmed-meshheading:11983282-Rats,
pubmed-meshheading:11983282-Rats, Wistar,
pubmed-meshheading:11983282-Receptors, Neurokinin-1,
pubmed-meshheading:11983282-Somatostatin,
pubmed-meshheading:11983282-Substance P,
pubmed-meshheading:11983282-Substantia Nigra,
pubmed-meshheading:11983282-Synaptic Transmission,
pubmed-meshheading:11983282-Tyrosine 3-Monooxygenase,
pubmed-meshheading:11983282-Vesicular Acetylcholine Transport Proteins,
pubmed-meshheading:11983282-Vesicular Transport Proteins
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pubmed:year |
2002
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pubmed:articleTitle |
Synaptic association of dopaminergic axon terminals and neurokinin-1 receptor-expressing intrinsic neurons in the striatum of the rat.
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pubmed:affiliation |
Department of Anatomy and K.K. Leung Brain Research Center, The Fourth Military Medical University, Xi'an 710032, People's Republic of China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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