Linked Life Data

11983232

Source:http://linkedlifedata.com/resource/pubmed/id/11983232

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pubmed-article:11983232pubmed:abstractTextPreviously, we have reported the development of a new quantitative-competitive polymerase chain reaction (qc-PCR) method to evaluate interferon-beta (IFNbeta) bioavailability in multiple sclerosis (MS) patients, by measuring mRNA of mixovirus resistance protein A (MxA). Here we show that our assay is also able to assess IFNalpha bioavailability in hepatitis C virus (HCV) patients treated with different IFNalpha regimens. Indeed, our method was able to detect a slight constitutive expression of MxA mRNA in untreated HCV patients (median=70 fgMxA/pgGAPDH) and a significant induction 12 h after the first IFNalpha administration (median=750 fgMxA/pgGAPDH).lld:pubmed
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pubmed-article:11983232pubmed:dateRevised2005-5-27lld:pubmed
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pubmed-article:11983232pubmed:articleTitleEvaluation of IFNalpha bioavailability by MxA mRNA in HCV patients.lld:pubmed
pubmed-article:11983232pubmed:affiliationCentro Sclerosi Multipla and Laboratorio di Neurobiologia Clinica, Divisione Universitaria di Neurologia, Azienda Ospedaliera S. Luigi, Università di Torino, Regione Gonzole 10, 10043 Orbassano, Italy. NSGLB@TIN.ITlld:pubmed
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