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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2002-5-1
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pubmed:abstractText |
Previously, we have reported the development of a new quantitative-competitive polymerase chain reaction (qc-PCR) method to evaluate interferon-beta (IFNbeta) bioavailability in multiple sclerosis (MS) patients, by measuring mRNA of mixovirus resistance protein A (MxA). Here we show that our assay is also able to assess IFNalpha bioavailability in hepatitis C virus (HCV) patients treated with different IFNalpha regimens. Indeed, our method was able to detect a slight constitutive expression of MxA mRNA in untreated HCV patients (median=70 fgMxA/pgGAPDH) and a significant induction 12 h after the first IFNalpha administration (median=750 fgMxA/pgGAPDH).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0022-1759
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
262
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-90
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pubmed:dateRevised |
2005-5-27
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pubmed:meshHeading |
pubmed-meshheading:11983232-Antiviral Agents,
pubmed-meshheading:11983232-Biological Availability,
pubmed-meshheading:11983232-GTP-Binding Proteins,
pubmed-meshheading:11983232-Hepatitis C,
pubmed-meshheading:11983232-Humans,
pubmed-meshheading:11983232-Interferon-alpha,
pubmed-meshheading:11983232-Leukocytes, Mononuclear,
pubmed-meshheading:11983232-Polymerase Chain Reaction,
pubmed-meshheading:11983232-Proteins,
pubmed-meshheading:11983232-RNA, Messenger
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pubmed:year |
2002
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pubmed:articleTitle |
Evaluation of IFNalpha bioavailability by MxA mRNA in HCV patients.
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pubmed:affiliation |
Centro Sclerosi Multipla and Laboratorio di Neurobiologia Clinica, Divisione Universitaria di Neurologia, Azienda Ospedaliera S. Luigi, Università di Torino, Regione Gonzole 10, 10043 Orbassano, Italy. NSGLB@TIN.IT
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pubmed:publicationType |
Journal Article
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