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rdf:type |
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lifeskim:mentions |
umls-concept:C0024554,
umls-concept:C0040223,
umls-concept:C0178601,
umls-concept:C0205307,
umls-concept:C0681850,
umls-concept:C0750729,
umls-concept:C1280500,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C2349001,
umls-concept:C2350290,
umls-concept:C2603343,
umls-concept:C2697811
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pubmed:issue |
2
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pubmed:dateCreated |
2002-4-30
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pubmed:abstractText |
Prepulse inhibition (PPI) of startle is a measure of sensorimotor gating that is deficient in schizophrenia and in rodents treated with dopamine (DA) agonists. Reduced PPI is reported in normal humans treated with direct or indirect DA agonists. To facilitate future studies, we assessed the time course of DA agonist effects on PPI in humans, for both direct (bromocriptine: 1.25, 2.5 mg; pergolide: 0.025, 0.1 mg) and indirect DA agonists (amphetamine: 20 mg; amantadine: 200 mg) ( n=6-10/dose).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
|
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0033-3158
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
161
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
189-201
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11981599-Adolescent,
pubmed-meshheading:11981599-Adult,
pubmed-meshheading:11981599-Amantadine,
pubmed-meshheading:11981599-Amphetamine,
pubmed-meshheading:11981599-Analysis of Variance,
pubmed-meshheading:11981599-Blood Pressure,
pubmed-meshheading:11981599-Bromocriptine,
pubmed-meshheading:11981599-Dopamine Agonists,
pubmed-meshheading:11981599-Double-Blind Method,
pubmed-meshheading:11981599-Heart Rate,
pubmed-meshheading:11981599-Humans,
pubmed-meshheading:11981599-Male,
pubmed-meshheading:11981599-Pergolide,
pubmed-meshheading:11981599-Psychomotor Performance,
pubmed-meshheading:11981599-Startle Reaction,
pubmed-meshheading:11981599-Time Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Dopamine agonist effects on startle and sensorimotor gating in normal male subjects: time course studies.
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pubmed:affiliation |
Department of Psychiatry, UCSD School of Medicine, 9500 Gilman Drive, La Jolla, CA 92093-0804, USA. nswerdlow@ucsd.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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