Source:http://linkedlifedata.com/resource/pubmed/id/11981372
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2002-4-30
|
| pubmed:abstractText |
We recently reported the finding of phylogenetically related HIV-1 BG intersubtype recombinant and G subtype nonrecombinant viruses circulating among injecting drug users in the region of Galicia in northwestern Spain. Here, we report the characterization of near full-length genome sequences of nine of these viruses (seven BG recombinant and two of nonrecombinant G subtype), obtained from epidemiologically unlinked individuals. Bootscan analysis reveals that six recombinant viruses share an identical mosaic structure, with two intersubtype breakpoints delimiting a B subtype segment comprising most of Env gp120 and the external portion of Env gp41, with the remaining portions of the genome being of subtype G, thus mimicking a pseudotype virion structure. The seventh BG recombinant virus exhibits breakpoints in env coincident with the other BG viruses but contains additional B subtype segments in gag and pol. In phylogenetic trees of complete genomes and of the B subtype segment of env, all seven BG viruses group in a monophyletic cluster. G subtype portions of the BG viruses group uniformly with the newly derived nonrecombinant G subtype viruses of Galicia in bootscan analysis, which points to the locally circulating G subtype strain as parental of the recombinants. These results allow us to define a new HIV-1 circulating recombinant form (CRF14_BG), the first reported to originate in Western Europe.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1525-4135
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| pubmed:author |
pubmed-author:CarmonaRocíoR,
pubmed-author:CuevasLaureanoL,
pubmed-author:CuevasMaría TeresaMT,
pubmed-author:DelgadoElenaE,
pubmed-author:Diz-ArenJulioJ,
pubmed-author:LosadaElenaE,
pubmed-author:MedranoLeandroL,
pubmed-author:MirallesCeliaC,
pubmed-author:NájeraRafaelR,
pubmed-author:OcampoAntonioA,
pubmed-author:Ojea-de CastroRafaelR,
pubmed-author:Pérez-AlvarezLucíaL,
pubmed-author:Rodríguez-PérezRaúlR,
pubmed-author:SierraMaríaM,
pubmed-author:TaboadaJosé AntonioJA,
pubmed-author:ThomsonMichael MMM,
pubmed-author:Vázquez-de PargaElenaE,
pubmed-author:VillahermosaMaría LuisaML
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
29
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
536-43
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11981372-Female,
pubmed-meshheading:11981372-Genome, Viral,
pubmed-meshheading:11981372-HIV Envelope Protein gp120,
pubmed-meshheading:11981372-HIV Envelope Protein gp41,
pubmed-meshheading:11981372-HIV Infections,
pubmed-meshheading:11981372-HIV-1,
pubmed-meshheading:11981372-Humans,
pubmed-meshheading:11981372-Male,
pubmed-meshheading:11981372-Molecular Sequence Data,
pubmed-meshheading:11981372-Recombination, Genetic,
pubmed-meshheading:11981372-Sequence Analysis, DNA,
pubmed-meshheading:11981372-Spain,
pubmed-meshheading:11981372-Substance Abuse, Intravenous,
pubmed-meshheading:11981372-Virion
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Identification of a newly characterized HIV-1 BG intersubtype circulating recombinant form in Galicia, Spain, which exhibits a pseudotype-like virion structure.
|
| pubmed:affiliation |
Instituto de Salud Carlos III, Ctra. Majadahonda-Pozuelo, Km. 2, 28220 Majadahonda, Madrid, Spain.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|