| pubmed-article:11980639 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11980639 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:11980639 | lifeskim:mentions | umls-concept:C0543467 | lld:lifeskim |
| pubmed-article:11980639 | lifeskim:mentions | umls-concept:C0278996 | lld:lifeskim |
| pubmed-article:11980639 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:11980639 | lifeskim:mentions | umls-concept:C0965644 | lld:lifeskim |
| pubmed-article:11980639 | lifeskim:mentions | umls-concept:C0085415 | lld:lifeskim |
| pubmed-article:11980639 | lifeskim:mentions | umls-concept:C1333897 | lld:lifeskim |
| pubmed-article:11980639 | lifeskim:mentions | umls-concept:C1704838 | lld:lifeskim |
| pubmed-article:11980639 | lifeskim:mentions | umls-concept:C1521761 | lld:lifeskim |
| pubmed-article:11980639 | lifeskim:mentions | umls-concept:C1519672 | lld:lifeskim |
| pubmed-article:11980639 | lifeskim:mentions | umls-concept:C1521996 | lld:lifeskim |
| pubmed-article:11980639 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11980639 | pubmed:dateCreated | 2002-4-30 | lld:pubmed |
| pubmed-article:11980639 | pubmed:abstractText | Hypoxia within head and neck squamous cell carcinoma (HNSCC) predicts a poor response to radiotherapy and poor prognosis. Hypoxia-inducible factor (HIF)-1 and HIF-2 are nuclear transcription factors that regulate the cellular response to hypoxia and are important for solid tumor growth and survival. Overexpression of HIF-1alpha and HIF-2alpha was demonstrated in three HNSCC cell lines under hypoxia and tumor tissue versus normal tissue (n = 20, HIF-1alpha, P = 0.023; HIF-2alpha, P = 0.013). On immunostaining, HIF-1alpha and HIF-2alpha expression were localized to tumor nuclei; HIF-2alpha expression was also seen in tumor-associated macrophages. Expression of HIF-1alpha in surgically treated patients with HNSCC (n = 79) was associated with improved disease-free survival (P = 0.016) and overall survival (P = 0.027). | lld:pubmed |
| pubmed-article:11980639 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11980639 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11980639 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11980639 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11980639 | pubmed:month | May | lld:pubmed |
| pubmed-article:11980639 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:11980639 | pubmed:author | pubmed-author:HarrisAdrian... | lld:pubmed |
| pubmed-article:11980639 | pubmed:author | pubmed-author:BeasleyNigel... | lld:pubmed |
| pubmed-article:11980639 | pubmed:author | pubmed-author:TurleyHelenH | lld:pubmed |
| pubmed-article:11980639 | pubmed:author | pubmed-author:LeekRussellR | lld:pubmed |
| pubmed-article:11980639 | pubmed:author | pubmed-author:AlamMohammedM | lld:pubmed |
| pubmed-article:11980639 | pubmed:author | pubmed-author:CoxGraham JGJ | lld:pubmed |
| pubmed-article:11980639 | pubmed:author | pubmed-author:GatterKevinK | lld:pubmed |
| pubmed-article:11980639 | pubmed:author | pubmed-author:MillardPeterP | lld:pubmed |
| pubmed-article:11980639 | pubmed:author | pubmed-author:FuggleSueS | lld:pubmed |
| pubmed-article:11980639 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11980639 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11980639 | pubmed:volume | 62 | lld:pubmed |
| pubmed-article:11980639 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11980639 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11980639 | pubmed:pagination | 2493-7 | lld:pubmed |
| pubmed-article:11980639 | pubmed:dateRevised | 2007-4-11 | lld:pubmed |
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| pubmed-article:11980639 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11980639 | pubmed:articleTitle | Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients. | lld:pubmed |
| pubmed-article:11980639 | pubmed:affiliation | Oxford Centre for Head and Neck Oncology, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom. | lld:pubmed |
| pubmed-article:11980639 | pubmed:publicationType | Journal Article | lld:pubmed |
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