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rdf:type |
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lifeskim:mentions |
umls-concept:C0030705,
umls-concept:C0085415,
umls-concept:C0278996,
umls-concept:C0439849,
umls-concept:C0543467,
umls-concept:C0965644,
umls-concept:C1333897,
umls-concept:C1519672,
umls-concept:C1521761,
umls-concept:C1521996,
umls-concept:C1704838
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pubmed:issue |
9
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pubmed:dateCreated |
2002-4-30
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pubmed:abstractText |
Hypoxia within head and neck squamous cell carcinoma (HNSCC) predicts a poor response to radiotherapy and poor prognosis. Hypoxia-inducible factor (HIF)-1 and HIF-2 are nuclear transcription factors that regulate the cellular response to hypoxia and are important for solid tumor growth and survival. Overexpression of HIF-1alpha and HIF-2alpha was demonstrated in three HNSCC cell lines under hypoxia and tumor tissue versus normal tissue (n = 20, HIF-1alpha, P = 0.023; HIF-2alpha, P = 0.013). On immunostaining, HIF-1alpha and HIF-2alpha expression were localized to tumor nuclei; HIF-2alpha expression was also seen in tumor-associated macrophages. Expression of HIF-1alpha in surgically treated patients with HNSCC (n = 79) was associated with improved disease-free survival (P = 0.016) and overall survival (P = 0.027).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0008-5472
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2493-7
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pubmed:dateRevised |
2007-4-11
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pubmed:meshHeading |
pubmed-meshheading:11980639-Adolescent,
pubmed-meshheading:11980639-Adult,
pubmed-meshheading:11980639-Aged,
pubmed-meshheading:11980639-Aged, 80 and over,
pubmed-meshheading:11980639-Basic Helix-Loop-Helix Transcription Factors,
pubmed-meshheading:11980639-Carcinoma, Squamous Cell,
pubmed-meshheading:11980639-Disease-Free Survival,
pubmed-meshheading:11980639-HeLa Cells,
pubmed-meshheading:11980639-Head and Neck Neoplasms,
pubmed-meshheading:11980639-Humans,
pubmed-meshheading:11980639-Hypoxia-Inducible Factor 1, alpha Subunit,
pubmed-meshheading:11980639-Immunohistochemistry,
pubmed-meshheading:11980639-L-Lactate Dehydrogenase,
pubmed-meshheading:11980639-Middle Aged,
pubmed-meshheading:11980639-Necrosis,
pubmed-meshheading:11980639-Survival Rate,
pubmed-meshheading:11980639-Trans-Activators,
pubmed-meshheading:11980639-Transcription Factors,
pubmed-meshheading:11980639-Treatment Outcome
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pubmed:year |
2002
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|
pubmed:articleTitle |
Hypoxia-inducible factors HIF-1alpha and HIF-2alpha in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients.
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pubmed:affiliation |
Oxford Centre for Head and Neck Oncology, Radcliffe Infirmary, Oxford OX2 6HE, United Kingdom.
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pubmed:publicationType |
Journal Article
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