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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-4-30
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pubmed:abstractText |
Retinol binding protein (RBP) in the plasma of rats treated with D-galactosamine was monitored to establish whether its level can be used to evaluate drug-induced hepatotoxicity. Blood was withdrawn by heart puncture at 0 hours and 12 hours after the administration of D-galactosamine (400 mg/kg body weight i.p.) to rats. Lactate dehydrogenase (LDH) and alanine aminotransferase (ALT) in the plasma at 12 hours after the D-galactosamine administration significantly increased, while RBP in the plasma at that time significantly decreased. On the other hand, the albumin in the plasma was unaffected at 12 hours after the D-galactosamine administration. Thus RBP seems to monitor different aspects of drug-induced hepatotoxicity than LDH and ALT and to detect the drug-induced hepatotoxicity more sensitively than albumin level under the present conditions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0258-851X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
61-5
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11980363-Alanine Transaminase,
pubmed-meshheading:11980363-Animals,
pubmed-meshheading:11980363-Drug-Induced Liver Injury,
pubmed-meshheading:11980363-Galactosamine,
pubmed-meshheading:11980363-Injections, Intraperitoneal,
pubmed-meshheading:11980363-L-Lactate Dehydrogenase,
pubmed-meshheading:11980363-Rats,
pubmed-meshheading:11980363-Rats, Wistar,
pubmed-meshheading:11980363-Retinol-Binding Proteins,
pubmed-meshheading:11980363-Retinol-Binding Proteins, Plasma,
pubmed-meshheading:11980363-Serum Albumin
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pubmed:articleTitle |
Evaluation of drug-induced hepatotoxicity by plasma retinol binding protein.
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pubmed:affiliation |
Department of Biopharmaceutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cyo, Inage-ku, Chiba 263-8522, Japan.
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pubmed:publicationType |
Journal Article
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