Linked Life Data

11980314

Source:http://linkedlifedata.com/resource/pubmed/id/11980314

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2002-4-30
pubmed:abstractText
PURPOSE: Lyme borreliosis is a multisystemic infection caused by the spirochaete Borrelia burgdorferi. In European endemic areas like northeast France, articular manifestations are, after neuroborreliosis, the most frequent extra-cutaneous features observed. Among the pathogenic species of Borrelia, Borrelia burgdorferi sensu stricto is the most frequently identified during Lyme arthritis, but others species also seem to be involved. CURRENT KNOWLEDGE AND KEY POINTS: The diagnosis of Lyme arthritis is usually based on combined clinical data and serological laboratory tests. In atypical forms, detection of bacterial DNA could be useful. While mechanisms involved in acute Lyme arthritis are beginning to be better understood, the pathogenesis of chronic arthritis, which concerns about 10% of the patients, remains unknown. Two hypotheses are proposed to explain the prolonged evolution of the articular disease: a chronic persistence of Borrelia burgdorferi, which evades the host immune system within the joint and/or an autoimmune mechanism by molecular mimicry. The antibiotic therapy is codified in acute arthritis, but is not really adapted in chronic Lyme arthritis or post-Lyme syndrome. FUTURE PROSPECTS AND PROJECTS: To prevent the disease, the vaccine available in the United States does not offer complete protection and is not useful in Europe since the species heterogeneity is important for the outer surface protein A. A better understanding of Lyme disease pathogenesis can subsequently lead to new therapeutic or preventive approaches.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0248-8663
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
378-85
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
[Rheumatologic manifestations of Lyme borreliosis].
pubmed:affiliation
Service de rhumatologie, hôpital de Hautepierre, CHU, 1, avenue Molière, 67098 Strasbourg, France. jean.sibilia@wanadoo.fr
pubmed:publicationType
Journal Article, English Abstract