Linked Life Data

11979756

Source:http://linkedlifedata.com/resource/pubmed/id/11979756

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2002-4-30
pubmed:abstractText
The incidence of overt diabetes was completely prevented by a single intradermal inoculation of Mycobacterium leprae (M. leprae) into Non-obese diabetic (NOD) mice as young as 6-7 weeks. Partial prevention was also observed in cases when 65 kD heat-shock protein (hsp65) with Freund's incomplete adjuvant (FIA) was injected, and no prevention was observed by 38 kD with FIA immunization. Histological examination of pancreata demonstrated that control and M. leprae-immunized mice at 24 weeks of age developed the insulitis even though the number of lymphocytes infiltrated in the treated ones were less than the controls. However, later, at 47 weeks of age, even the immunized mice become to develop very severe insulitis. Thus, M. leprae-immunization did not prevent the incidences of insulitis. The spontaneous development of serum antibody against hsp65 and 38 kD protein preceded the onset of diabetes in NOD mice. Lymphocytes response, IFN-gamma and IL-10 production of splenocytes cultures stimulated with hsp65 were examined to clue the reasons for the prevention of IDDM incidence by M. leprae immunization. The spontaneous development of anti-hsp65 T lymphocytes preceded the outbreak of overt IDDM in control NOD mice, but also appeared in M. leprae immunized cases in which the IDDM incidence was prevented, and both control and M. leprae immunized groups produced IFN-gamma and IL-10 by stimulation with hsp65.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1342-3681
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
31-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2002
pubmed:articleTitle
Prevention of diabetes in non-obese diabetic mice by a single immunization with Mycobacterium leprae.
pubmed:affiliation
Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aobacho, Higashimurayama-shi, Tokyo 189-0002, Japan. h-nomagc@nih.go.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't