Source:http://linkedlifedata.com/resource/pubmed/id/11978780
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2002-4-29
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pubmed:abstractText |
Acute graft-versus-host disease (GvHD) is a serious complication after allogeneic bone marrow transplantation. Donor-derived T cells infiltrate recipient target organs and cause severe tissue damage, often leading to death of the affected patient. Tissue destruction is a direct result of donor CD8+ T cell activation and cell-mediated cytotoxicity. IL-18 is a novel pro-inflammatory cytokine with potent T(h)1 immune response-promoting and cytotoxic T lymphocyte (CTL)-inducing activity. IL-18 is strongly induced in experimental mouse models and human patients with acute GvHD. However, the precise role of IL-18 in the development of acute GvHD is still unknown. In this study, we have used IL-18-binding protein, a soluble IL-18 decoy receptor, to specifically neutralize IL-18 in vivo and in vitro. Our results demonstrate that IL-18 is induced during GvHD. However, its effect in the induction of GvHD appears to be redundant, since neutralization of IL-18 does not alter any disease parameter analyzed. Our study further shows that IFN-gamma production and CTL induction upon activation by T cell mitogens or by alloantigen does not involve IL-18-mediated amplification, in contrast to lipopolysaccharide-induced IFN-gamma production. We conclude that IL-18 expression correlates with the course of GvHD; however, its effect is dispensable for IFN-gamma and CTL induction for the initiation phase of this disease, most likely due to direct, IL-18-independent, CTL activation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0953-8178
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pubmed:author |
pubmed-author:AlouaniSamiS,
pubmed-author:ArnoldDianaD,
pubmed-author:BrunnerThomasT,
pubmed-author:ChvatchkoYolandeY,
pubmed-author:CimaIgorI,
pubmed-author:FrutschiCorinaC,
pubmed-author:GraberPierreP,
pubmed-author:HerrenSimonS,
pubmed-author:JakobSabineS,
pubmed-author:JuillardPierreP,
pubmed-author:MuellerChristophC,
pubmed-author:WasemChristophC
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
503-11
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11978780-Animals,
pubmed-meshheading:11978780-Graft vs Host Disease,
pubmed-meshheading:11978780-Interferon-gamma,
pubmed-meshheading:11978780-Interleukin-12,
pubmed-meshheading:11978780-Interleukin-18,
pubmed-meshheading:11978780-Lipopolysaccharides,
pubmed-meshheading:11978780-Lymphocyte Activation,
pubmed-meshheading:11978780-Mice,
pubmed-meshheading:11978780-Mice, Inbred C57BL,
pubmed-meshheading:11978780-Mice, Inbred DBA,
pubmed-meshheading:11978780-T-Lymphocytes, Cytotoxic
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pubmed:year |
2002
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pubmed:articleTitle |
IL-18-independent cytotoxic T lymphocyte activation and IFN-gamma production during experimental acute graft-versus-host disease.
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pubmed:affiliation |
Division of Immunopathology, Institute of Pathology, University of Bern, Murtenstrasse 31, PO Box 62, 3010, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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