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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0008633,
umls-concept:C0011860,
umls-concept:C0017347,
umls-concept:C0028754,
umls-concept:C0032659,
umls-concept:C0240795,
umls-concept:C0332307,
umls-concept:C0392360,
umls-concept:C1416480,
umls-concept:C1517692,
umls-concept:C1556084,
umls-concept:C1705535,
umls-concept:C2717880
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pubmed:issue |
5
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pubmed:dateCreated |
2002-4-29
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pubmed:abstractText |
The Lim domain homeobox gene (Isl-1) is a positional candidate gene for obesity that maps on chromosome 5q11-q13, a locus linked to BMI and leptin levels in French Caucasians. Isl-1 might be involved in body weight regulation and glucose homeostasis via the activation of proglucagon gene expression, which encodes for glucagon and glucagon-like peptides. By mutation screening of 72 obese subjects, we identified three single-nucleotide polymorphisms (SNPs) in the Isl1 gene. The allele frequencies in the morbidly obese group did not differ from that of the control group. In the obese group, the -47G allele was associated with a decreased risk of type 2 diabetes (odds ratio 0.41, P = 0.019). The AG bearers displayed a higher maximal BMI than the AA bearers in the whole obese group (P = 0.026) as well as in the type 2 diabetic obese subgroup (P = 0.014). In obese families, this allele was not preferentially transmitted from heterozygous parents to their obese siblings, indicating that Isl-1 does not contribute to the linkage with obesity on 5cen-q. However, in French Caucasian morbidly obese subjects, the Isl1-47A-->G SNP may modulate the risk for type 2 diabetes and may increase body weight in diabetic morbidly obese subjects.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0012-1797
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1640-3
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11978668-Adult,
pubmed-meshheading:11978668-Aged,
pubmed-meshheading:11978668-Chromosomes, Human, Pair 5,
pubmed-meshheading:11978668-Diabetes Mellitus,
pubmed-meshheading:11978668-Diabetes Mellitus, Type 2,
pubmed-meshheading:11978668-Female,
pubmed-meshheading:11978668-France,
pubmed-meshheading:11978668-Genetic Linkage,
pubmed-meshheading:11978668-Genetic Predisposition to Disease,
pubmed-meshheading:11978668-Genotype,
pubmed-meshheading:11978668-Homeodomain Proteins,
pubmed-meshheading:11978668-Humans,
pubmed-meshheading:11978668-LIM-Homeodomain Proteins,
pubmed-meshheading:11978668-Male,
pubmed-meshheading:11978668-Middle Aged,
pubmed-meshheading:11978668-Nerve Tissue Proteins,
pubmed-meshheading:11978668-Obesity,
pubmed-meshheading:11978668-Obesity, Morbid,
pubmed-meshheading:11978668-Risk Factors,
pubmed-meshheading:11978668-Transcription Factors
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pubmed:year |
2002
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pubmed:articleTitle |
Positional candidate gene analysis of Lim domain homeobox gene (Isl-1) on chromosome 5q11-q13 in a French morbidly obese population suggests indication for association with type 2 diabetes.
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pubmed:affiliation |
Institute of Biology, Centre National de la Recherche Scientifique (CNRS) 80-90, Lille, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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