| pubmed-article:11978633 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11978633 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:11978633 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
| pubmed-article:11978633 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:11978633 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:11978633 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:11978633 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:11978633 | lifeskim:mentions | umls-concept:C0019630 | lld:lifeskim |
| pubmed-article:11978633 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:11978633 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:11978633 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11978633 | pubmed:dateCreated | 2002-4-29 | lld:pubmed |
| pubmed-article:11978633 | pubmed:abstractText | Soluble HLA-DR401 or -DR404 tetramers containing a peptide corresponding to an immunodominant epitope from human GAD65 were used to analyze peripheral blood T-cells of newly diagnosed type 1 diabetic patients and at-risk subjects. Peripheral blood mononuclear cells were expanded on antigen-presenting cells presenting GAD65 peptide and subsequently activated with specific plate-bound class II-peptide monomers. T-cell activation defined in flow cytometry by CD4(high) and/or CD25 markers were observed in all type 1 diabetic patients and some at-risk subjects, but not in normal control subjects. The activated T-cells stained positive with tetramers containing the GAD65 epitope 555-567. Tetramer-positive cells were CD4(high) T-cells with high avidity for an immunodominant GAD65 T-cell epitope. Phenotyping of T-cells utilizing HLA class II tetramers provides a new tool to characterize the autoimmune response in type 1 diabetes. | lld:pubmed |
| pubmed-article:11978633 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11978633 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11978633 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11978633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11978633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11978633 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11978633 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11978633 | pubmed:month | May | lld:pubmed |
| pubmed-article:11978633 | pubmed:issn | 0012-1797 | lld:pubmed |
| pubmed-article:11978633 | pubmed:author | pubmed-author:ReijonenHelen... | lld:pubmed |
| pubmed-article:11978633 | pubmed:author | pubmed-author:KwokWilliam... | lld:pubmed |
| pubmed-article:11978633 | pubmed:author | pubmed-author:NepomGerald... | lld:pubmed |
| pubmed-article:11978633 | pubmed:author | pubmed-author:NovakErik JEJ | lld:pubmed |
| pubmed-article:11978633 | pubmed:author | pubmed-author:LiuAndrew WAW | lld:pubmed |
| pubmed-article:11978633 | pubmed:author | pubmed-author:KochikSharonS | lld:pubmed |
| pubmed-article:11978633 | pubmed:author | pubmed-author:HeningerAnneA | lld:pubmed |
| pubmed-article:11978633 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11978633 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:11978633 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11978633 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11978633 | pubmed:pagination | 1375-82 | lld:pubmed |
| pubmed-article:11978633 | pubmed:dateRevised | 2007-10-24 | lld:pubmed |
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| pubmed-article:11978633 | pubmed:meshHeading | pubmed-meshheading:11978633... | lld:pubmed |
| pubmed-article:11978633 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11978633 | pubmed:articleTitle | Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects. | lld:pubmed |
| pubmed-article:11978633 | pubmed:affiliation | Virginia Mason Research Center, Benaroya Research Institute, Seattle, Washington 98101-2795, USA. reijonen@vmresearch.org | lld:pubmed |
| pubmed-article:11978633 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11978633 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:11978633 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11978633 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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