Linked Life Data

11978629

Source:http://linkedlifedata.com/resource/pubmed/id/11978629

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pubmed-article:11978629pubmed:abstractTextAge-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoantibodies to GAD65 (GADAs), ICA512/IA-2, insulin, and islet cells were determined by logistic regression analysis in 971 incident patients with type 1 diabetes and 702 control subjects aged 0-34 years. GADAs were associated with HLA-DQ2 in young but not in older patients (P = 0.009). Autoantibodies to insulin were negatively associated with age (P < 0.0001) but positively associated with DQ8 (P = 0.03) and with INS VNTR (P = 0.04), supporting possible immune tolerance induction. ICA512/IA-2 were negatively associated with age (P < 0.0001) and with DQ2 (P < 0.0001) but positively associated with DQ8 (P = 0.04). Males were more likely than females to be negative for GADA (P < 0.0001), autoantibodies to islet cells (P = 0.04), and all four autoantibody markers (P = 0.004). The CTLA-4 3' end microsatellite marker was not associated with any of the autoantibodies. We conclude that age and genetic factors such as HLA-DQ and INS VNTR need to be combined with islet autoantibody markers when evaluating the risk for type 1 diabetes development.lld:pubmed
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pubmed-article:11978629pubmed:articleTitleGenetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.lld:pubmed
pubmed-article:11978629pubmed:affiliationDepartment of Statistics and Actuarial Science, Simon Fraser University, Burnaby, Canada.lld:pubmed
pubmed-article:11978629pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11978629pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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