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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2002-4-29
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pubmed:abstractText |
Age-dependent associations between type 1 diabetes risk genes HLA, INS VNTR, and CTLA-4 and autoantibodies to GAD65 (GADAs), ICA512/IA-2, insulin, and islet cells were determined by logistic regression analysis in 971 incident patients with type 1 diabetes and 702 control subjects aged 0-34 years. GADAs were associated with HLA-DQ2 in young but not in older patients (P = 0.009). Autoantibodies to insulin were negatively associated with age (P < 0.0001) but positively associated with DQ8 (P = 0.03) and with INS VNTR (P = 0.04), supporting possible immune tolerance induction. ICA512/IA-2 were negatively associated with age (P < 0.0001) and with DQ2 (P < 0.0001) but positively associated with DQ8 (P = 0.04). Males were more likely than females to be negative for GADA (P < 0.0001), autoantibodies to islet cells (P = 0.04), and all four autoantibody markers (P = 0.004). The CTLA-4 3' end microsatellite marker was not associated with any of the autoantibodies. We conclude that age and genetic factors such as HLA-DQ and INS VNTR need to be combined with islet autoantibody markers when evaluating the risk for type 1 diabetes development.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0012-1797
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pubmed:author |
pubmed-author:BlohméGöranG,
pubmed-author:BreslowNormanN,
pubmed-author:DahlquistGiselaG,
pubmed-author:DayHeather LHL,
pubmed-author:Diabetes Incidence in Sweden Study Group,
pubmed-author:GrahamJinkoJ,
pubmed-author:HagopianWilliam AWA,
pubmed-author:HoodLeroyL,
pubmed-author:Janer-VillanuevaMartaM,
pubmed-author:KockumIngridI,
pubmed-author:Landin-OlssonMonaM,
pubmed-author:LernmarkAkeA,
pubmed-author:LiLou ShengLS,
pubmed-author:LoweRobert MRM,
pubmed-author:PalmerJerry PJP,
pubmed-author:SanjeeviCarani BCB,
pubmed-author:SchaeferJonathan BJB,
pubmed-author:SundkvistGöranG,
pubmed-author:Swedish Childhood Diabetes Study Group,
pubmed-author:ZarghamiMarjanM
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1346-55
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11978629-Adolescent,
pubmed-meshheading:11978629-Adult,
pubmed-meshheading:11978629-Age of Onset,
pubmed-meshheading:11978629-Autoantibodies,
pubmed-meshheading:11978629-Biological Markers,
pubmed-meshheading:11978629-Child,
pubmed-meshheading:11978629-Child, Preschool,
pubmed-meshheading:11978629-Diabetes Mellitus, Type 1,
pubmed-meshheading:11978629-Female,
pubmed-meshheading:11978629-Genotype,
pubmed-meshheading:11978629-HLA-DQ Antigens,
pubmed-meshheading:11978629-Humans,
pubmed-meshheading:11978629-Infant,
pubmed-meshheading:11978629-Infant, Newborn,
pubmed-meshheading:11978629-Islets of Langerhans,
pubmed-meshheading:11978629-Logistic Models,
pubmed-meshheading:11978629-Male,
pubmed-meshheading:11978629-Risk Factors,
pubmed-meshheading:11978629-Seroepidemiologic Studies,
pubmed-meshheading:11978629-Sex Distribution
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pubmed:year |
2002
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pubmed:articleTitle |
Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes.
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pubmed:affiliation |
Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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