Source:http://linkedlifedata.com/resource/pubmed/id/11978400
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2002-4-29
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| pubmed:databankReference | |
| pubmed:abstractText |
In seeking genetic factors that may control the extended behavioural maturation of adult honeybees we found that inositol 1,4,5-trisphosphate (IP(3)) 3-kinase, a key enzyme in the IP(3)-mediated signalling cascade, is differentially expressed in brains of naive, newly emerged bees and experienced foragers. DNA sequencing yielded a contig of 21.5 kb spanning the honeybee IP(3)K locus and a 3' flanking gene similar to a transcription factor NFR-kappa-B. The IP(3)K locus gives rise to three differentially expressed major transcripts produced by alternative splicing that encode proteins with identical, highly conserved C-termini and distinct, non-conserved N-terminal domains. The type A transcript is dominant in the adult brain and its level of expression increases threefold during the first 4 days of adult development. The type B message is expressed in brains of naive bees, but is also found in the thorax and abdomen, whereas transcript C is expressed largely in non-neural tissues and in the antenna. In contrast to type A message, the brain levels of transcript B decrease during the first 4 days of adult life. Our data are evaluated in the context of the contrasting behavioural phenotypes of immature and experienced worker honeybees.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol 1,4,5-trisphosphate...,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotransferases (Alcohol Group...,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
|
| pubmed:issn |
0169-328X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
28
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| pubmed:volume |
99
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
92-101
|
| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11978400-Animals,
pubmed-meshheading:11978400-Bees,
pubmed-meshheading:11978400-Behavior, Animal,
pubmed-meshheading:11978400-Brain,
pubmed-meshheading:11978400-Cloning, Molecular,
pubmed-meshheading:11978400-DNA,
pubmed-meshheading:11978400-Female,
pubmed-meshheading:11978400-Gene Expression Regulation, Developmental,
pubmed-meshheading:11978400-Genes,
pubmed-meshheading:11978400-Molecular Sequence Data,
pubmed-meshheading:11978400-Neurons,
pubmed-meshheading:11978400-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:11978400-Protein Isoforms,
pubmed-meshheading:11978400-Protein Structure, Tertiary,
pubmed-meshheading:11978400-RNA, Messenger,
pubmed-meshheading:11978400-Sequence Homology, Amino Acid,
pubmed-meshheading:11978400-Sequence Homology, Nucleic Acid,
pubmed-meshheading:11978400-Viscera
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| pubmed:year |
2002
|
| pubmed:articleTitle |
Molecular profiling of behavioural development: differential expression of mRNAs for inositol 1,4,5-trisphosphate 3-kinase isoforms in naive and experienced honeybees (Apis mellifera).
|
| pubmed:affiliation |
Visual Sciences, Research School of Biological Sciences, The Australian National University, Canberra ACT 0200, Australia.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|