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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2002-4-29
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pubmed:abstractText |
Intracoronary ultrasound studies in humans show that chronic remodelling rather than neointimal hyperplasia is the mechanism of restenosis. Stent implantation limits this remodelling process and significantly reduces restenosis. MMP3 (Stromelysin-1), a member of the matrix metalloproteinase family may play a role in this remodelling. We used a functional polymorphism (with alleles designated 5A or 6A) in the promoter of the MMP3 gene to examine the possible role of MMP3 in restenosis.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0195-668X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 The European Society of Cardiology.
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
721-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11977998-Aged,
pubmed-meshheading:11977998-Alleles,
pubmed-meshheading:11977998-Angioplasty, Balloon, Coronary,
pubmed-meshheading:11977998-Blood Vessel Prosthesis Implantation,
pubmed-meshheading:11977998-Coronary Restenosis,
pubmed-meshheading:11977998-Coronary Stenosis,
pubmed-meshheading:11977998-Female,
pubmed-meshheading:11977998-Follow-Up Studies,
pubmed-meshheading:11977998-France,
pubmed-meshheading:11977998-Genotype,
pubmed-meshheading:11977998-Humans,
pubmed-meshheading:11977998-Male,
pubmed-meshheading:11977998-Matrix Metalloproteinase 3,
pubmed-meshheading:11977998-Middle Aged,
pubmed-meshheading:11977998-Polymorphism, Genetic,
pubmed-meshheading:11977998-Promoter Regions, Genetic,
pubmed-meshheading:11977998-Risk Factors,
pubmed-meshheading:11977998-Stents
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pubmed:year |
2002
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pubmed:articleTitle |
The 5A6A polymorphism in the promoter of the stromelysin-1 (MMP3) gene as a risk factor for restenosis.
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pubmed:affiliation |
Centre for Cardiovascular Genetics, Department of Medicine, UCLMS, The Rayne Institute, London, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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