Source:http://linkedlifedata.com/resource/pubmed/id/11975828
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2002-4-26
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| pubmed:abstractText |
The aim of the study was to assess whether stents covered with a membrane of polytetrafluoroethylene spanned over the mashes of a sandwich-configured double stent (n = 15) prevent migration of smooth muscle cells through stent spaces, leading to less neointima formation compared with uncovered stainless steel stents (n = 14) in iliac arteries of male Chinchilla Bastard rabbits (n = 18). Lumen stenosis was assessed by quantitative angiography immediately before the animals were killed 5 weeks after stent deployment. Neointima formation was quantified by histomorphometric analysis. There were large regional and individual differences in neointima formation, leading locally to a significantly higher degree of stenosis in covered stents (histologically, 76.0 +/- 13.7 vs. 62.9 +/- 12.9%; angiographically, 33.5 +/- 21.1 vs. 7.8 +/- 8.8%) compared with uncovered stents, though mean neointimal and lumen area values were not significantly different. In conclusion, polytetrafluoroethylene-covered stents do not prevent neointima formation compared with uncovered stents. Although the membrane reduces local smooth muscle cell migration, the neointima hyperplasia at the proximal and distal ends of a covered stent stimulates migration along its longitudinal axis. In this stent-restenosis model, regional and individual proliferation processes and not the membrane-covering strut-to-strut distances determine lumen restenosis.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1521-737X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
4
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
18-25
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11975828-Animals,
pubmed-meshheading:11975828-Biocompatible Materials,
pubmed-meshheading:11975828-Coronary Angiography,
pubmed-meshheading:11975828-Coronary Restenosis,
pubmed-meshheading:11975828-Coronary Stenosis,
pubmed-meshheading:11975828-Coronary Vessels,
pubmed-meshheading:11975828-Disease Models, Animal,
pubmed-meshheading:11975828-Equipment Safety,
pubmed-meshheading:11975828-Immunohistochemistry,
pubmed-meshheading:11975828-Materials Testing,
pubmed-meshheading:11975828-Metals,
pubmed-meshheading:11975828-Polytetrafluoroethylene,
pubmed-meshheading:11975828-Probability,
pubmed-meshheading:11975828-Rabbits,
pubmed-meshheading:11975828-Reference Values,
pubmed-meshheading:11975828-Sensitivity and Specificity,
pubmed-meshheading:11975828-Statistics, Nonparametric,
pubmed-meshheading:11975828-Stents,
pubmed-meshheading:11975828-Tunica Intima
|
| pubmed:articleTitle |
Neointima formation after stent implantation in an experimental model of restenosis: polytetrafluoroethylene-covered versus uncovered stainless steel stents.
|
| pubmed:affiliation |
Heart Center, Department for Internal Medicine/Cardiology, University of Leipzig, Germany. sickp@medizin.uni-leipzig.de
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| pubmed:publicationType |
Journal Article,
Comparative Study
|