pubmed-article:11975761 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0021080 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0025417 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0021079 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0205246 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0231204 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
pubmed-article:11975761 | lifeskim:mentions | umls-concept:C0205191 | lld:lifeskim |
pubmed-article:11975761 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:11975761 | pubmed:dateCreated | 2002-4-26 | lld:pubmed |
pubmed-article:11975761 | pubmed:abstractText | Administration of mercuric chloride into susceptible rats and mice induces a systemic autoimmune disease, which is characterized by a T-cell-dependent polyclonal B-cell activation, an increase in serum levels of immunoglobulin (Ig)G1 and IgE, production of antibodies of different specificities and development of renal IgG deposits. A peculiar feature of mercury-induced autoimmunity is that the polyclonal B-cell activation spontaneously disappears in spite of continuous injection of mercury. The exact mechanism(s) for autoregulation of mercury-induced autoimmunity is not well understood. In the present study, we analysed the regulation of mercury-induced immune/autoimmune responses in mice and tested whether spontaneous downregulation of these responses is owing to a general immunosuppression. Mercury-susceptible [SJL (H-2s)] and -resistant [DBA/2 (H-2d)] mice were injected with mercury for 4, 10, 15 and 17 weeks. Immune/autoimmune responses were monitored in these mice. Thereafter, mercury-injected mice for 17 weeks were further immunized with horse red blood cells (HRBC) to study whether the subsequent humoral immune response to a foreign antigen is suppressed. We found that except for IgG1 anti-nucleolar antibody production and renal IgG1 deposition, other characteristics of mercury-induced autoimmunity were downregulated in SJL (H-2s) mice after chronic treatment with mercury. However, these mice did not show any reduction in the number of splenic antibody-secreting cells and/or in serum titres of specific IgM, IgG1 and IgG2a anti-HRBC antibodies in response to HRBC as compared with naïve mice. Similarly, in mercury-resistant DBA/2 (H-2d) mice, chronic treatment with mercury did not either suppress specific antibody responses against HRBC. Our findings show that the autoregulation of mercury-induced immune/autoimmune responses observed after chronic treatment with mercury is not owing to a general immunosuppression. | lld:pubmed |
pubmed-article:11975761 | pubmed:language | eng | lld:pubmed |
pubmed-article:11975761 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11975761 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11975761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11975761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11975761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11975761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11975761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11975761 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11975761 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11975761 | pubmed:month | May | lld:pubmed |
pubmed-article:11975761 | pubmed:issn | 0300-9475 | lld:pubmed |
pubmed-article:11975761 | pubmed:author | pubmed-author:MellstedtHH | lld:pubmed |
pubmed-article:11975761 | pubmed:author | pubmed-author:RabbaniHH | lld:pubmed |
pubmed-article:11975761 | pubmed:author | pubmed-author:Abedi-Valuger... | lld:pubmed |
pubmed-article:11975761 | pubmed:author | pubmed-author:RoetherSS | lld:pubmed |
pubmed-article:11975761 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11975761 | pubmed:volume | 55 | lld:pubmed |
pubmed-article:11975761 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11975761 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11975761 | pubmed:pagination | 493-502 | lld:pubmed |
pubmed-article:11975761 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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pubmed-article:11975761 | pubmed:year | 2002 | lld:pubmed |
pubmed-article:11975761 | pubmed:articleTitle | Spontaneous downregulation of antibody/autoantibody synthesis in susceptible mice upon chronic exposure to mercuric chloride is not owing to a general immunosuppression. | lld:pubmed |
pubmed-article:11975761 | pubmed:affiliation | Department of Immunology, The Wenner-Gren Institute, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden. | lld:pubmed |
pubmed-article:11975761 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11975761 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11975761 | lld:pubmed |