Source:http://linkedlifedata.com/resource/pubmed/id/11975761
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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0004358,
umls-concept:C0013081,
umls-concept:C0021079,
umls-concept:C0021080,
umls-concept:C0025417,
umls-concept:C0026809,
umls-concept:C0205191,
umls-concept:C0205246,
umls-concept:C0205359,
umls-concept:C0220781,
umls-concept:C0231204,
umls-concept:C0332157,
umls-concept:C1883254
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pubmed:issue |
5
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pubmed:dateCreated |
2002-4-26
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pubmed:abstractText |
Administration of mercuric chloride into susceptible rats and mice induces a systemic autoimmune disease, which is characterized by a T-cell-dependent polyclonal B-cell activation, an increase in serum levels of immunoglobulin (Ig)G1 and IgE, production of antibodies of different specificities and development of renal IgG deposits. A peculiar feature of mercury-induced autoimmunity is that the polyclonal B-cell activation spontaneously disappears in spite of continuous injection of mercury. The exact mechanism(s) for autoregulation of mercury-induced autoimmunity is not well understood. In the present study, we analysed the regulation of mercury-induced immune/autoimmune responses in mice and tested whether spontaneous downregulation of these responses is owing to a general immunosuppression. Mercury-susceptible [SJL (H-2s)] and -resistant [DBA/2 (H-2d)] mice were injected with mercury for 4, 10, 15 and 17 weeks. Immune/autoimmune responses were monitored in these mice. Thereafter, mercury-injected mice for 17 weeks were further immunized with horse red blood cells (HRBC) to study whether the subsequent humoral immune response to a foreign antigen is suppressed. We found that except for IgG1 anti-nucleolar antibody production and renal IgG1 deposition, other characteristics of mercury-induced autoimmunity were downregulated in SJL (H-2s) mice after chronic treatment with mercury. However, these mice did not show any reduction in the number of splenic antibody-secreting cells and/or in serum titres of specific IgM, IgG1 and IgG2a anti-HRBC antibodies in response to HRBC as compared with naïve mice. Similarly, in mercury-resistant DBA/2 (H-2d) mice, chronic treatment with mercury did not either suppress specific antibody responses against HRBC. Our findings show that the autoregulation of mercury-induced immune/autoimmune responses observed after chronic treatment with mercury is not owing to a general immunosuppression.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Mercuric Chloride
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0300-9475
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
493-502
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11975761-Animals,
pubmed-meshheading:11975761-Autoantibodies,
pubmed-meshheading:11975761-Autoimmunity,
pubmed-meshheading:11975761-Down-Regulation,
pubmed-meshheading:11975761-Erythrocytes,
pubmed-meshheading:11975761-Female,
pubmed-meshheading:11975761-Horses,
pubmed-meshheading:11975761-Immunoglobulin E,
pubmed-meshheading:11975761-Immunoglobulin G,
pubmed-meshheading:11975761-Interferon-gamma,
pubmed-meshheading:11975761-Interleukin-4,
pubmed-meshheading:11975761-Kidney Glomerulus,
pubmed-meshheading:11975761-Mercuric Chloride,
pubmed-meshheading:11975761-Mice,
pubmed-meshheading:11975761-Mice, Inbred DBA,
pubmed-meshheading:11975761-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11975761-Spleen
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pubmed:year |
2002
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pubmed:articleTitle |
Spontaneous downregulation of antibody/autoantibody synthesis in susceptible mice upon chronic exposure to mercuric chloride is not owing to a general immunosuppression.
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pubmed:affiliation |
Department of Immunology, The Wenner-Gren Institute, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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