Source:http://linkedlifedata.com/resource/pubmed/id/11973641
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0036525,
umls-concept:C0041904,
umls-concept:C0162493,
umls-concept:C0205250,
umls-concept:C0205314,
umls-concept:C0242379,
umls-concept:C0679622,
umls-concept:C0684249,
umls-concept:C0750502,
umls-concept:C1426122,
umls-concept:C1515655,
umls-concept:C1522484,
umls-concept:C1539222
|
| pubmed:issue |
18
|
| pubmed:dateCreated |
2002-4-25
|
| pubmed:databankReference | |
| pubmed:abstractText |
Most lung cancer patients are unfortunately uncurable and die because of widespread metastases, thus indicating the importance of identification of molecules with a crucial role in this process. Our previous expression profiling analysis of a highly metastatic lung cancer cell line, NCI-H460-LNM35, and its parental low metastatic line, NCI-H460-N15, revealed significant up-regulation of both known and unknown genes in LNM35. In this study, we describe the isolation and detailed characterizations of a novel gene, named CLCP1, which corresponds to one of such expression sequence tags with up-regulated expression in LNM35. The CLCP1 gene was found to encode a protein with 775 amino acids with structural similarities to, but distinct from neuropilins, cell surface receptors for VEGF165 and semaphorins. Notably, CLCP1 was shown to be up-regulated not only in LNM35 in association with its acquisition of metastatic phenotype during in vivo selection, but also in a significant fraction of lung cancers in vivo with high frequency in metastatic lesions, warranting future studies for a better understanding of the molecular mechanisms of lung cancer metastasis.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0950-9232
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
25
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2822-8
|
| pubmed:dateRevised |
2010-5-26
|
| pubmed:meshHeading |
pubmed-meshheading:11973641-Adenocarcinoma,
pubmed-meshheading:11973641-Adult,
pubmed-meshheading:11973641-Amino Acid Sequence,
pubmed-meshheading:11973641-Base Sequence,
pubmed-meshheading:11973641-Carcinoma, Large Cell,
pubmed-meshheading:11973641-Carcinoma, Small Cell,
pubmed-meshheading:11973641-Carcinoma, Squamous Cell,
pubmed-meshheading:11973641-Chemical Fractionation,
pubmed-meshheading:11973641-Cloning, Molecular,
pubmed-meshheading:11973641-DNA, Complementary,
pubmed-meshheading:11973641-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:11973641-Humans,
pubmed-meshheading:11973641-Lung Neoplasms,
pubmed-meshheading:11973641-Membrane Proteins,
pubmed-meshheading:11973641-Molecular Sequence Data,
pubmed-meshheading:11973641-Neoplasm Metastasis,
pubmed-meshheading:11973641-Neoplasm Proteins,
pubmed-meshheading:11973641-Sequence Homology, Nucleic Acid,
pubmed-meshheading:11973641-Transfection,
pubmed-meshheading:11973641-Tumor Cells, Cultured,
pubmed-meshheading:11973641-Up-Regulation
|
| pubmed:year |
2002
|
| pubmed:articleTitle |
Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo.
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| pubmed:affiliation |
Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|