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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-4-25
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pubmed:abstractText |
The past year has seen significant advances in our understanding of critical roles of negative immunoregulatory signals delivered through the B7-CD28 superfamily in regulating T cell activation and tolerance. Structural data on CTLA-4 have provided novel insights into the inhibitory functions of CTLA-4. Initial characterization of the PD-1-PD-1-ligand pathway has revealed that this pathway can downregulate TCR- and CD28-mediated signals. Recent studies indicate that ICOS exerts distinct effects at different phases of an immune response: ICOS can inhibit as well as stimulate T cell responses.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD274,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CD274 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/ICOS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator...,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/PDCD1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/PDCD1LG2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Ligand 2...,
http://linkedlifedata.com/resource/pubmed/chemical/Programmed Cell Death 1 Receptor,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0952-7915
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
391-6
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11973140-Animals,
pubmed-meshheading:11973140-Antigens, CD,
pubmed-meshheading:11973140-Antigens, CD274,
pubmed-meshheading:11973140-Antigens, CD28,
pubmed-meshheading:11973140-Antigens, CD80,
pubmed-meshheading:11973140-Antigens, Differentiation,
pubmed-meshheading:11973140-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:11973140-Antigens, Surface,
pubmed-meshheading:11973140-Apoptosis Regulatory Proteins,
pubmed-meshheading:11973140-Blood Proteins,
pubmed-meshheading:11973140-CTLA-4 Antigen,
pubmed-meshheading:11973140-Humans,
pubmed-meshheading:11973140-Immunoconjugates,
pubmed-meshheading:11973140-Inducible T-Cell Co-Stimulator Protein,
pubmed-meshheading:11973140-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:11973140-Membrane Glycoproteins,
pubmed-meshheading:11973140-Peptides,
pubmed-meshheading:11973140-Programmed Cell Death 1 Ligand 2 Protein,
pubmed-meshheading:11973140-Programmed Cell Death 1 Receptor,
pubmed-meshheading:11973140-T-Lymphocytes
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pubmed:year |
2002
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pubmed:articleTitle |
Negative co-receptors on lymphocytes.
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pubmed:affiliation |
Immunology Research Division, Department of Pathology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA. rgreenwald@rics.bwh.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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