|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2002-4-25
|
|
pubmed:abstractText |
The kinase activity of lymphocyte-specific tyrosine kinase p56lck (Lck) upon physiological major histocompatibility complex (MHC) recognition by normal mature T cells was examined. Recognition of the target MHC molecules by T cells induced phosphorylation of the zeta-chain without obvious enhancement of the background Lck activity. There was no sign of enhancement of Lck through putative T-cell receptor (TCR)-independent class II MHC/CD4 interactions either. As has been reported, cross-linking of CD4 molecules by antibodies induced a marked enhancement of Lck activity. However, it did not have an immediate relevance to TCR-mediated signal transduction, as judged from the lack of detectable de novo phosphorylation of zeta-chain and the absence of functional responses of T cells. These results strongly favour the model in which TCR-mediated signal transduction does not involve aggregation-dependent enhancement of Lck, suggesting that the signal can be triggered simply by the recruitment of already active Lck with basal kinase activity through the formation of a TCR/MHC/CD4 ternary complex.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-10477578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-10755618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-10825739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-10843386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-1423621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-1534242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-1717631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-2118992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-2142477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-2481585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-2784195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-2787934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-6195085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-6300242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-7525706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-7615501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-7648394,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-7753171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-8228817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-8293463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-8355789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-9021998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-9143695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-9169445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-9208843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-9489702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11972631-9806633
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0019-2805
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
106
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
46-52
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:11972631-Animals,
pubmed-meshheading:11972631-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11972631-Cell Aggregation,
pubmed-meshheading:11972631-Cells, Cultured,
pubmed-meshheading:11972631-Lymphocyte Specific Protein Tyrosine Kinase p56(lck),
pubmed-meshheading:11972631-Major Histocompatibility Complex,
pubmed-meshheading:11972631-Mice,
pubmed-meshheading:11972631-Mice, Transgenic,
pubmed-meshheading:11972631-Phosphorylation,
pubmed-meshheading:11972631-Receptors, Antigen, T-Cell,
pubmed-meshheading:11972631-Signal Transduction,
pubmed-meshheading:11972631-T-Lymphocytes
|
|
pubmed:year |
2002
|
|
pubmed:articleTitle |
Lack of evidence for aggregation-dependent enhancement of p56lck in the signal transduction upon major histocompatibility complex recognition by mature T cells.
|
|
pubmed:affiliation |
Department of Immunology, Kitasato University School of Medicine, Sagamihara, Japan. eshima@med.kitasato-u.ac.jp
|
|
pubmed:publicationType |
Journal Article
|
