| pubmed-article:11972532 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11972532 | lifeskim:mentions | umls-concept:C0239307 | lld:lifeskim |
| pubmed-article:11972532 | lifeskim:mentions | umls-concept:C0005961 | lld:lifeskim |
| pubmed-article:11972532 | lifeskim:mentions | umls-concept:C0032269 | lld:lifeskim |
| pubmed-article:11972532 | lifeskim:mentions | umls-concept:C1504389 | lld:lifeskim |
| pubmed-article:11972532 | lifeskim:mentions | umls-concept:C0205281 | lld:lifeskim |
| pubmed-article:11972532 | lifeskim:mentions | umls-concept:C0038951 | lld:lifeskim |
| pubmed-article:11972532 | lifeskim:mentions | umls-concept:C0205087 | lld:lifeskim |
| pubmed-article:11972532 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11972532 | pubmed:dateCreated | 2002-4-25 | lld:pubmed |
| pubmed-article:11972532 | pubmed:abstractText | Streptococcus pneumoniae (S. pneumoniae) may cause severe and lethal infections months and years following stem cell transplantation (SCT). In a prospective survey over a 3.5-year period, we assessed the incidence, risk factors and outcome for invasive pneumococcal infection (IPI) following SCT. Fifty-one episodes of IPI were reported: 43 episodes after bone marrow transplantation (BMT) and 8 after peripheral blood stem cell transplantation (PBSCT); 35 after allogeneic SCT and 16 after autologous SCT. Seven IPI episodes, all bacteraemias, were defined as early, occurring 1-35 d (median 3 d) post transplantation. Forty-four episodes were defined as late (> or = 100 d post SCT), occurring 4 months to 10 years (median 17 months) post transplantation. The incidences of early and late IPI were 2.03/1000 and 8.63/1000 transplantations respectively (P = 0.001). A higher incidence of late IPI was observed after BMT than after PBSCT (10.99 versus 3.23/1000; P < 0.01) and after allogeneic versus autologous SCT (12.20 versus 4.60/1000; P < 0.01). There was a higher estimated incidence of IPI in allogeneic patients with than in those without graft-versus-host disease (GVHD) (18.85 versus 8.25/1000; P = 0.015). The mortality rate was 20%, including 2/7 of early and 8/44 of late IPI. S. pneumoniae is a rare but important complication during the aplastic phase after SCT. In conclusion, S. pneumoniae is a significant cause of morbidity late post-transplantation, especially in allogeneic patients, and particularly those with GVHD. The high IPI mortality rate, both early and late post-transplantation, requires preventive approaches, mainly effective immunization. | lld:pubmed |
| pubmed-article:11972532 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11972532 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11972532 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11972532 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11972532 | pubmed:month | May | lld:pubmed |
| pubmed-article:11972532 | pubmed:issn | 0007-1048 | lld:pubmed |
| pubmed-article:11972532 | pubmed:author | pubmed-author:MartinoRodrig... | lld:pubmed |
| pubmed-article:11972532 | pubmed:author | pubmed-author:ShawPeter JPJ | lld:pubmed |
| pubmed-article:11972532 | pubmed:author | pubmed-author:PrenticeH... | lld:pubmed |
| pubmed-article:11972532 | pubmed:author | pubmed-author:EngelhardDanD | lld:pubmed |
| pubmed-article:11972532 | pubmed:author | pubmed-author:CordonnierCat... | lld:pubmed |
| pubmed-article:11972532 | pubmed:author | pubmed-author:LjungmanPerP | lld:pubmed |
| pubmed-article:11972532 | pubmed:author | pubmed-author:ParkalliTertt... | lld:pubmed |
| pubmed-article:11972532 | pubmed:author | pubmed-author:GuentherChris... | lld:pubmed |
| pubmed-article:11972532 | pubmed:author | pubmed-author:DekkerAdriaan... | lld:pubmed |
| pubmed-article:11972532 | pubmed:author | pubmed-author:GustavssonAni... | lld:pubmed |
| pubmed-article:11972532 | pubmed:author | pubmed-author:NurnbergerWen... | lld:pubmed |
| pubmed-article:11972532 | pubmed:author | pubmed-author:Infectious... | lld:pubmed |
| pubmed-article:11972532 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11972532 | pubmed:volume | 117 | lld:pubmed |
| pubmed-article:11972532 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11972532 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11972532 | pubmed:pagination | 444-50 | lld:pubmed |
| pubmed-article:11972532 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:11972532 | pubmed:meshHeading | pubmed-meshheading:11972532... | lld:pubmed |
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| pubmed-article:11972532 | pubmed:meshHeading | pubmed-meshheading:11972532... | lld:pubmed |
| pubmed-article:11972532 | pubmed:meshHeading | pubmed-meshheading:11972532... | lld:pubmed |
| pubmed-article:11972532 | pubmed:meshHeading | pubmed-meshheading:11972532... | lld:pubmed |
| pubmed-article:11972532 | pubmed:meshHeading | pubmed-meshheading:11972532... | lld:pubmed |
| pubmed-article:11972532 | pubmed:meshHeading | pubmed-meshheading:11972532... | lld:pubmed |
| pubmed-article:11972532 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11972532 | pubmed:articleTitle | Early and late invasive pneumococcal infection following stem cell transplantation: a European Bone Marrow Transplantation survey. | lld:pubmed |
| pubmed-article:11972532 | pubmed:affiliation | Department of Pediatrics, Hadassah University Hospital and Hebrew University Hadassah Medical School, Ein Karem, Jerusalem, Israel. engelhard@hadassah.org.il | lld:pubmed |
| pubmed-article:11972532 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11972532 | pubmed:publicationType | Multicenter Study | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11972532 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11972532 | lld:pubmed |
