Source:http://linkedlifedata.com/resource/pubmed/id/11972532
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2002-4-25
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| pubmed:abstractText |
Streptococcus pneumoniae (S. pneumoniae) may cause severe and lethal infections months and years following stem cell transplantation (SCT). In a prospective survey over a 3.5-year period, we assessed the incidence, risk factors and outcome for invasive pneumococcal infection (IPI) following SCT. Fifty-one episodes of IPI were reported: 43 episodes after bone marrow transplantation (BMT) and 8 after peripheral blood stem cell transplantation (PBSCT); 35 after allogeneic SCT and 16 after autologous SCT. Seven IPI episodes, all bacteraemias, were defined as early, occurring 1-35 d (median 3 d) post transplantation. Forty-four episodes were defined as late (> or = 100 d post SCT), occurring 4 months to 10 years (median 17 months) post transplantation. The incidences of early and late IPI were 2.03/1000 and 8.63/1000 transplantations respectively (P = 0.001). A higher incidence of late IPI was observed after BMT than after PBSCT (10.99 versus 3.23/1000; P < 0.01) and after allogeneic versus autologous SCT (12.20 versus 4.60/1000; P < 0.01). There was a higher estimated incidence of IPI in allogeneic patients with than in those without graft-versus-host disease (GVHD) (18.85 versus 8.25/1000; P = 0.015). The mortality rate was 20%, including 2/7 of early and 8/44 of late IPI. S. pneumoniae is a rare but important complication during the aplastic phase after SCT. In conclusion, S. pneumoniae is a significant cause of morbidity late post-transplantation, especially in allogeneic patients, and particularly those with GVHD. The high IPI mortality rate, both early and late post-transplantation, requires preventive approaches, mainly effective immunization.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0007-1048
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| pubmed:author |
pubmed-author:CordonnierCatherineC,
pubmed-author:DekkerAdriaan WAW,
pubmed-author:EngelhardDanD,
pubmed-author:GuentherChristineC,
pubmed-author:GustavssonAnitaA,
pubmed-author:Infectious Disease Working Party of the European Bone Marrow...,
pubmed-author:LjungmanPerP,
pubmed-author:MartinoRodrigoR,
pubmed-author:NurnbergerWenzelW,
pubmed-author:ParkalliTerttuT,
pubmed-author:PrenticeH GrantHG,
pubmed-author:ShawPeter JPJ
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| pubmed:issnType |
Print
|
| pubmed:volume |
117
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
444-50
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11972532-Adolescent,
pubmed-meshheading:11972532-Adult,
pubmed-meshheading:11972532-Australia,
pubmed-meshheading:11972532-Bacteremia,
pubmed-meshheading:11972532-Bone Marrow Transplantation,
pubmed-meshheading:11972532-Child,
pubmed-meshheading:11972532-Child, Preschool,
pubmed-meshheading:11972532-Europe,
pubmed-meshheading:11972532-Female,
pubmed-meshheading:11972532-Follow-Up Studies,
pubmed-meshheading:11972532-Graft vs Host Disease,
pubmed-meshheading:11972532-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11972532-Humans,
pubmed-meshheading:11972532-Incidence,
pubmed-meshheading:11972532-Male,
pubmed-meshheading:11972532-Meningitis, Pneumococcal,
pubmed-meshheading:11972532-Middle Aged,
pubmed-meshheading:11972532-Pneumococcal Infections,
pubmed-meshheading:11972532-Postoperative Complications,
pubmed-meshheading:11972532-Prospective Studies,
pubmed-meshheading:11972532-Risk Factors,
pubmed-meshheading:11972532-Time Factors,
pubmed-meshheading:11972532-Transplantation, Autologous,
pubmed-meshheading:11972532-Transplantation, Homologous
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Early and late invasive pneumococcal infection following stem cell transplantation: a European Bone Marrow Transplantation survey.
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| pubmed:affiliation |
Department of Pediatrics, Hadassah University Hospital and Hebrew University Hadassah Medical School, Ein Karem, Jerusalem, Israel. engelhard@hadassah.org.il
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| pubmed:publicationType |
Journal Article,
Multicenter Study
|